Architecture-Aware Augmentation: A Hybrid Deep Learning and Machine Learning Approach for Enhanced Parkinson's Disease Detection.

Parkinson's Disease (PD) is a progressive neurodegenerative disorder affecting millions worldwide. Early detection is crucial for improving patient outcomes. Spiral drawing analysis has emerged as a non-invasive tool to detect early motor impairments associated with PD. This study examines the performance of hybrid deep learning and machine learning models in detecting PD using spiral drawings, with a focus on the impact of data augmentation techniques. We compare the accuracy of Vision Transformer (ViT) with K-Nearest Neighbors (KNN), Convolutional Neural Networks (CNN) with Support Vector Machines (SVM), and Residual Neural Networks (ResNet-50) with Logistic Regression, evaluating their performance on both augmented and non-augmented data. Our findings reveal that ViT with KNN, initially achieving 96.77% accuracy on unaugmented data, experienced a notable decline across all augmentation techniques, suggesting it relies heavily on global patterns in spiral drawings. In contrast, ResNet-50 with Logistic Regression showed consistent improvement with data augmentation, reaching 93.55% accuracy when rotation and flipping techniques were applied. These results highlight that hybrid models respond differently to augmentation, and careful selection of augmentation strategies is necessary for optimizing model performance. Our study provides important insights into the development of reliable diagnostic tools for early PD detection, emphasizing the need for appropriate augmentation techniques in medical image analysis.