Li Tian-Gang, Wang Gang, Xie Fang, Yao Juan-Min, Yang Lan, Wang Meng-Lin, Wang Jian, Xing Lin, Nie Fang
Department of Ultrasound Diagnosis, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China; Department of Ultrasound Diagnosis, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu Province, China.
Department of Ultrasound Diagnosis, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu Province, China.
Eur J Obstet Gynecol Reprod Biol. 2020 Nov;254:6-10. doi: 10.1016/j.ejogrb.2020.08.047. Epub 2020 Sep 2.
To investigate the incidence of the single umbilical artery (SUA) malformation and postpartum outcomes in a retrospective analysis of 781 fetuses.
This retrospective analysis included 781 pregnant women carrying singleton fetuses diagnosed with SUA at Gansu Provincial Maternal and Child-care Hospital between 2013 and 2019. Detailed data on maternal and fetal characteristics and postpartum outcomes were obtained.
In total, 624 (79.9 %) fetuses were diagnosed with isolated SUA and 157 (20.1 %) fetuses had SUA together with other structural and/or chromosome abnormalities. The highest incidence of malformation was found in the urinary system, followed by the cardiovascular system and digestive system. The incidence of SUA was 59.1 % on the right side and 40.9 % on the left side. Fetuses with SUA and other abnormalities tended to have a lower mean birth weight (3061 g vs 3201 g, p < 0.01), but no difference in the rate of preterm delivery was noted.
After a diagnosis of SUA, structural observation of the fetus is required. The urinary, cardiovascular and digestive systems should be the focus of observation. If relevant malformations are found, then genetic testing must be performed. With isolated SUA, dynamic monitoring of biological indicators is recommended for lower birth weight, but genetic testing is not recommended.
通过对781例胎儿进行回顾性分析，探讨单脐动脉（SUA）畸形的发生率及产后结局。
本回顾性分析纳入了2013年至2019年期间在甘肃省妇幼保健院诊断为SUA的781例单胎妊娠孕妇。获取了母婴特征及产后结局的详细数据。
总共624例（79.9%）胎儿被诊断为孤立性SUA，157例（20.1%）胎儿合并其他结构和/或染色体异常。畸形发生率最高的是泌尿系统，其次是心血管系统和消化系统。SUA右侧发生率为59.1%，左侧为40.9%。合并其他异常的SUA胎儿平均出生体重往往较低（3061克对3201克，p<0.01），但早产率无差异。
诊断SUA后，需要对胎儿进行结构观察。泌尿系统、心血管系统和消化系统应作为观察重点。如果发现相关畸形，则必须进行基因检测。对于孤立性SUA，建议对出生体重较低者进行生物指标动态监测，但不建议进行基因检测。
