Shemesh Shai, Itzikovitch Ron, Atzmon Ran, Kadar Assaf
Department of Orthopaedic Surgery, Samson Assuta Ashdod University Hospital, 7 Ha'Refua Street, Ashdod 77476, Israel.
Faculty of Health Sciences, Ben Gurion University, Beer-Sheva 8410501, Israel.
J Clin Med. 2024 Dec 20;13(24):7801. doi: 10.3390/jcm13247801.
Olecranon bursitis (OB) involves fluid accumulation in the bursa, with common causes being trauma and preexisting conditions. Its incidence is difficult to quantify, and risk factors such as diabetes, obesity, and male gender are frequently noted. Hyperlipidemia has been linked to musculoskeletal disorders, but its role as a risk factor for OB remains unexplored. This study aimed to investigate the association between OB and hyperlipidemia, diabetes, obesity, cardiovascular disease, and statin use. A retrospective cohort study analyzed a large-scale database (2005-2020), ultimately including 10,301 patients with olecranon bursitis and 44,608 controls after applying exclusion criteria. Participants were aged 18-90 years, with BMI between 10 and 55. Key variables such as smoking, diabetes, hyperlipidemia, statin use, cardiovascular diseases (CVDs), and cerebrovascular accidents (CVAs) were analyzed. Logistic regression models were applied with stabilized inverse probability of treatment weighting (IPTW) to estimate odds ratios (ORs) for risk factors, and -values were adjusted using the Benjamini-Hochberg method. OB was significantly associated with male gender (OR: 1.406; < 0.0001), hyperlipidemia (OR: 1.239; < 0.0001), statin use (OR: 1.117; = 0.0035), and smoking (OR: 1.068; = 0.0094). Age and BMI were significant continuous variables influencing OB risk, particularly in older patients and those with elevated BMI. CVDs and diabetes were not significantly linked to OB. Hyperlipidemia increased OB risk, especially in males and individuals with higher BMI. Male gender, hyperlipidemia, and smoking are key risk factors for OB, with hyperlipidemia posing a notable risk in older individuals and those with higher BMI. Statin use did not significantly alter OB risk in hyperlipidemic patients. Further studies are needed to clarify the mechanisms behind these associations.
鹰嘴滑囊炎（OB）涉及滑囊内积液，常见病因是创伤和既往存在的疾病。其发病率难以量化，糖尿病、肥胖和男性等风险因素屡被提及。高脂血症与肌肉骨骼疾病有关，但其作为OB风险因素的作用仍未得到探索。本研究旨在调查OB与高脂血症、糖尿病、肥胖、心血管疾病及他汀类药物使用之间的关联。一项回顾性队列研究分析了一个大规模数据库（2005 - 2020年），在应用排除标准后，最终纳入了10301例鹰嘴滑囊炎患者和44608例对照。参与者年龄在18 - 90岁之间，体重指数（BMI）在10至55之间。对吸烟、糖尿病、高脂血症、他汀类药物使用、心血管疾病（CVD）和脑血管意外（CVA）等关键变量进行了分析。应用逻辑回归模型结合稳定的治疗权重逆概率（IPTW）来估计风险因素的比值比（OR），并使用Benjamini - Hochberg方法调整P值。OB与男性（OR：1.406；P < 0.0001）、高脂血症（OR：1.239；P < 0.0001）、他汀类药物使用（OR：1.117；P = 0.0035）和吸烟（OR：1.068；P = 0.0094）显著相关。年龄和BMI是影响OB风险的重要连续变量，尤其是在老年患者和BMI升高的患者中。CVD和糖尿病与OB无显著关联。高脂血症增加了OB风险，尤其是在男性和BMI较高的个体中。男性、高脂血症和吸烟是OB的关键风险因素，高脂血症在老年个体和BMI较高的个体中构成显著风险。他汀类药物使用并未显著改变高脂血症患者的OB风险。需要进一步研究以阐明这些关联背后的机制。
