Furtak Gabriela, Lerch Natalia, Kozłowski Mateusz, Tkacz Piotr, Piekara Emilia, Łagódka Maria, Durys Damian, Gutowska Izabela, Widecka Krystyna, Marchelek-Myśliwiec Małgorzata, Żwierełło Wojciech, Cymbaluk-Płoska Aneta
Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Int J Mol Sci. 2024 Dec 15;25(24):13449. doi: 10.3390/ijms252413449.
Anxiety is a subjective feeling of fear in response to stressful or threatening situations. Chronic diseases (such as chronic kidney disease) or the state after kidney transplantation are such situations and they may result in a decreased quality of life. The main aim of this research was to evaluate if the proteins IL-8, RANTES, MIG, MCP-1, IP-10, and IL-12p70 could be indicators of higher levels of anxiety or decreased quality of life in chronically ill women. The assessment was conducted using the STAI and SF-36 questionnaires and with the measurement of listed proteins from the patient's blood sample. The study group consisted of 107 women-101 patients from the Nephrological Clinic and 6 from the Dialysis Center. Both of the facilities are part of University Clinical Hospital No. 2 in Szczecin. Statistical analysis was performed using JASP software (JASP 0.18.3 version). Anxiety levels and quality of life correlations between STAI and SF-36 scores and individual variables were assessed. Logistic regression models were performed for both questionnaire outcomes: SF-36 and STAI. Lower quality of life was found in the group with a higher IL-8 concentration compared to the group of women with a lower IL-8 concentration. A positive weak correlation was found between a decreased quality of life and IL-8 and RANTES. A higher RANTES level increases the odds of a lower quality of life. This study shows that special care should be provided for chronically ill women (especially with CKD or after KTx) with a higher RANTES or IL-8 concentration. They would highly benefit from close monitoring of their mental health.
焦虑是一种因应压力或威胁情境而产生的主观恐惧感受。慢性疾病（如慢性肾脏病）或肾移植后的状态就是这样的情境，它们可能导致生活质量下降。本研究的主要目的是评估白细胞介素-8（IL-8）、调节激活正常T细胞表达和分泌的趋化因子（RANTES）、γ干扰素诱导单核因子（MIG）、单核细胞趋化蛋白-1（MCP-1）、干扰素诱导蛋白10（IP-10）和白细胞介素-12p70是否可作为慢性病女性焦虑水平较高或生活质量下降的指标。评估使用状态特质焦虑问卷（STAI）和简明健康状况调查问卷（SF-36）进行，并测量患者血样中的所列蛋白质。研究组由107名女性组成，其中101名来自肾脏病诊所，6名来自透析中心。这两个机构都是什切青第二大学临床医院的一部分。使用JASP软件（JASP 0.18.3版本）进行统计分析。评估了STAI和SF-36评分与个体变量之间的焦虑水平和生活质量相关性。对两个问卷结果（SF-36和STAI）都进行了逻辑回归模型分析。与IL-8浓度较低的女性组相比，IL-8浓度较高的组生活质量较低。发现生活质量下降与IL-8和RANTES之间存在微弱的正相关。较高的RANTES水平增加了生活质量较低的几率。本研究表明，对于RANTES或IL-8浓度较高的慢性病女性（尤其是患有慢性肾脏病或肾移植后的女性）应给予特别护理。她们将从密切监测其心理健康中受益匪浅。
