Coryell W, Tsuang M T
Am J Psychiatry. 1985 Apr;142(4):479-82. doi: 10.1176/ajp.142.4.479.
Using cross-sectional evaluations 40 years after index admissions, the authors compared depressed patients with mood-congruent and those with mood-incongruent psychotic features. These patients were then compared with patients with nonpsychotic major depression, schizophreniform disorder, or schizophrenia. Outcome in the mood-congruent group resembled that in the nonpsychotic group and was significantly better than that in the mood-incongruent group. Patients in this latter group, however, had significantly better follow-up scores than did schizophrenic patients. These findings are consistent with a short-term outcome and family history study and suggest that patients with major depression and mood-incongruent psychotic features constitute a more diagnostically heterogeneous group than do those with mood-congruent psychotic features.
作者利用首次入院40年后的横断面评估，将伴有心境一致和心境不一致精神病性特征的抑郁症患者进行了比较。然后将这些患者与非精神病性重度抑郁症、精神分裂症样障碍或精神分裂症患者进行比较。心境一致组的结果与非精神病组相似，且显著优于心境不一致组。然而，后一组患者的随访评分显著优于精神分裂症患者。这些发现与一项短期结局和家族史研究一致，表明伴有心境不一致精神病性特征的重度抑郁症患者比伴有心境一致精神病性特征的患者构成了一个诊断上更具异质性的群体。
