Zhu Zhini, Xia Qiu, Zhan Xinxia, Li Wenyuan, He Xuan, Wang Bo, Zhou Qizhi, Huang Jian, Ye Yong
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
Ganzhou Hake Biotech Co., Ltd., Ganzhou 341008, China.
Materials (Basel). 2024 Dec 20;17(24):6227. doi: 10.3390/ma17246227.
Diacylglycerol (DAG) is a functional oil but is rarely used in the cosmetic industry because low solubility, susceptibility to leakage and low viscosity to skin are still the main hurdles. A novel diacylglycerol nanostructured lipid carrier hydrogel (GTP-DAG-NLC-GEL) loaded with green tea polyphenol (GTP) was designed and successfully prepared to broaden DAG's application in cosmetics, which significantly improved GTP stability and skin stickiness of DAG. The results showed that DAG-NLC-GEL had good viscosity, which was 980 Pa·s when the shear rate was 5 rpm, and its viscosity decreased quickly with the increase in shear rate, making it easily expand on skin. Meanwhile, the encapsulation rate and drug loading of GTP in GDP-DAG-NLC-GEL reached 86.7% and 2.6%, respectively, and the DPPH free radicals scavenging rate and inhibition rate of the advanced glycation end-products (AGEs) were 85.46% and 89.72%, respectively, which indicate that GTP-DAG-NLC-GEL has significant skin sunscreen, antioxidant and anti-glycation activities. The GTP-loaded nanostructured lipid carrier hydrogel can be deemed to have great prospects for skin protection in cosmetics.
二酰基甘油（DAG）是一种功能性油脂，但由于其溶解度低、易泄漏以及对皮肤的低粘度等问题，在化妆品行业中很少使用。为了拓宽DAG在化妆品中的应用，设计并成功制备了一种负载绿茶多酚（GTP）的新型二酰基甘油纳米结构脂质载体水凝胶（GTP-DAG-NLC-GEL），该水凝胶显著提高了GTP的稳定性以及DAG对皮肤的粘附性。结果表明，DAG-NLC-GEL具有良好的粘度，当剪切速率为5 rpm时，其粘度为980 Pa·s，并且随着剪切速率的增加，其粘度迅速下降，使其易于在皮肤上铺展。同时，GTP在GDP-DAG-NLC-GEL中的包封率和载药量分别达到86.7%和2.6%，DPPH自由基清除率和晚期糖基化终产物（AGEs）抑制率分别为85.46%和89.72%，这表明GTP-DAG-NLC-GEL具有显著的皮肤防晒、抗氧化和抗糖化活性。负载GTP的纳米结构脂质载体水凝胶在化妆品皮肤保护方面具有很大的应用前景。
