Pastacaldi Chiara, Gaudioso Dario, Tegli Stefania
Laboratorio di Patologia Vegetale Molecolare, Dipartimento di Scienze e Tecnologie Agrarie, Alimentari Ambientali e Forestali, Università degli Studi di Firenze, Via della Lastruccia 10, 50019 Sesto Fiorentino, Firenze, Italy.
Microorganisms. 2024 Nov 27;12(12):2433. doi: 10.3390/microorganisms12122433.
In recent years, membrane transporters have attracted considerable interest regarding their involvement in the molecular dialogue occurring between microbes and their hosts. In particular, the multidrug and toxic compound extrusion (MATE) transporters form a family of integral membrane proteins, mainly involved in the efflux of toxic and xenobiotic compounds. They are present in all living organisms, both prokaryotes and eukaryotes, where they have a wide array of extremely different roles. In plants, MATE proteins are involved in many important physiological processes, such as plant development, as well as the active transport of several secondary metabolites. In microorganisms, they are mainly implicated in the efflux of toxic compounds and thus contribute to drug resistance. Conversely, information about the actual role of MATE transporters in the interaction between plants and microorganisms, including phytopathogens, is still limited, according to the number of publications available on this topic. Indeed, an understanding of their roles in the plant-pathogen interaction could be essential to increase the knowledge of their molecular conversation and to provide data for the design and development of innovative and sustainable anti-infective strategies to control and manage plant pathogens.
近年来，膜转运蛋白因其参与微生物与其宿主之间发生的分子对话而备受关注。特别是，多药和有毒化合物外排（MATE）转运蛋白构成了一类整合膜蛋白家族，主要参与有毒和外源性化合物的外排。它们存在于所有生物中，包括原核生物和真核生物，在这些生物中它们具有一系列极其不同的作用。在植物中，MATE蛋白参与许多重要的生理过程，如植物发育以及几种次生代谢产物的主动运输。在微生物中，它们主要与有毒化合物的外排有关，从而导致耐药性。相反，根据关于该主题的现有出版物数量，关于MATE转运蛋白在植物与微生物（包括植物病原体）相互作用中的实际作用的信息仍然有限。事实上，了解它们在植物 - 病原体相互作用中的作用对于增加对它们分子对话的认识以及为设计和开发创新和可持续的抗感染策略以控制和管理植物病原体提供数据可能至关重要。
