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通过肠-皮肤轴靶向炎症与皮肤衰老：HY7714衍生细胞外囊泡的作用

Targeting Inflammation and Skin Aging via the Gut-Skin Axis: The Role of HY7714-Derived Extracellular Vesicles.

作者信息

Lee Hayera, Lee Yun-Ha, Hong Dong-Ki, Mo Sung-Jun, Jeon Soomin, Park Soo-Dong, Shim Jae-Jung, Lee Jeong-Lyoul, Lee Jae-Hwan

机构信息

R&BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea.

出版信息

Microorganisms. 2024 Nov 30;12(12):2466. doi: 10.3390/microorganisms12122466.

DOI:10.3390/microorganisms12122466
PMID:39770669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11676968/
Abstract

Intestinal mucosal tissues are prone to infections, often leading to inflammation. Lactic acid bacteria in the gut can modulate these inflammatory responses, but the interaction between host cells and lactic acid bacteria remains unclear. This study examines how HY7714 alleviates intestinal inflammation using gut-on-a-chip technology and in vitro models. Inflammation was induced using a gut-on-a-chip, and changes in cell morphology and barrier function were analyzed. Extracellular vesicles (EVs) derived from HY7714-improved intestinal cell structure repaired damage and restored tight junction integrity. Additionally, they attenuated inflammatory cytokines by regulating the MyD88/mTOR/NF-κB signaling pathway. RNA sequencing revealed downregulation of vicinal oxygen chelate (VOC) family proteins and proline aminopeptidase, both linked to inflammation and extracellular matrix interactions in skin health. Therefore, we explored the effects of HY7714 EVs on skin cells. The findings showed that HY7714 EVs reduced cytotoxicity and downregulated metalloproteinase expression in skin cells exposed to UVB radiation, indicating their potential anti-aging and anti-photoaging properties. These findings suggest that HY7714-derived EVs enhance both intestinal and skin health by reducing inflammation and improving barrier function, with potential benefits for the gut-skin axis.

摘要

肠道黏膜组织容易受到感染，常常引发炎症。肠道中的乳酸菌能够调节这些炎症反应，但宿主细胞与乳酸菌之间的相互作用仍不清楚。本研究利用芯片肠道技术和体外模型，研究HY7714如何减轻肠道炎症。使用芯片肠道诱导炎症，并分析细胞形态和屏障功能的变化。源自HY7714的细胞外囊泡（EVs）改善了肠道细胞结构，修复了损伤并恢复了紧密连接的完整性。此外，它们通过调节MyD88/mTOR/NF-κB信号通路来减轻炎性细胞因子。RNA测序显示，邻位氧螯合（VOC）家族蛋白和脯氨酸氨肽酶的表达下调，这两者都与皮肤健康中的炎症和细胞外基质相互作用有关。因此，我们探索了HY7714 EVs对皮肤细胞的影响。研究结果表明，HY7714 EVs降低了暴露于紫外线B辐射的皮肤细胞的细胞毒性，并下调了金属蛋白酶的表达，表明它们具有潜在的抗衰老和抗光老化特性。这些研究结果表明，源自HY7714的EVs通过减轻炎症和改善屏障功能，增强了肠道和皮肤的健康，对肠-皮轴具有潜在益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7033/11676968/ca241b0679fe/microorganisms-12-02466-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7033/11676968/f9fa0710a31c/microorganisms-12-02466-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7033/11676968/00b5eb0ebdb2/microorganisms-12-02466-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7033/11676968/07fb031e5e7c/microorganisms-12-02466-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7033/11676968/26c64d936f30/microorganisms-12-02466-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7033/11676968/046b8ba332ef/microorganisms-12-02466-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7033/11676968/ca241b0679fe/microorganisms-12-02466-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7033/11676968/f9fa0710a31c/microorganisms-12-02466-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7033/11676968/00b5eb0ebdb2/microorganisms-12-02466-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7033/11676968/07fb031e5e7c/microorganisms-12-02466-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7033/11676968/26c64d936f30/microorganisms-12-02466-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7033/11676968/046b8ba332ef/microorganisms-12-02466-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7033/11676968/ca241b0679fe/microorganisms-12-02466-g006.jpg

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Contributions of the microbiome to intestinal inflammation in a gut-on-a-chip.
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Nano Converg. 2022 Feb 8;9(1):8. doi: 10.1186/s40580-022-00299-6.
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Effect of Extracellular Vesicles Derived From Q7 on Gut Microbiota and Ulcerative Colitis in Mice.Q7 来源的细胞外囊泡对小鼠肠道微生物群和溃疡性结肠炎的影响。
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