Batarfi Wafa Ali, Yunus Mohd Heikal Mohd, Hamid Adila A, Lee Yi Ting, Maarof Manira
Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, Kuala Lumpur 56000, Malaysia.
Department of Basic Medical Sciences, Hadhramout University College of Medicine, Al-Mukalla, Yemen.
Pharmaceutics. 2024 Nov 22;16(12):1504. doi: 10.3390/pharmaceutics16121504.
Inflammation and apoptosis are interrelated biological processes that have a significant impact on the advancement and growth of certain chronic diseases, such as cardiovascular problems, neurological conditions, and osteoarthritis. Recent research has emphasized that focusing on these mechanisms could result in novel therapeutic approaches that aim to decrease the severity of diseases and enhance patient outcomes. Hydroxytyrosol (HT), which is well-known for its ability to prevent oxidation, has been identified as a possible candidate for regulating both inflammation and apoptosis. In this review, we will highlight the multifaceted benefits of HT as a therapeutic agent in mitigating inflammation, apoptosis, and associated conditions. This review provides a comprehensive overview of the latest in vitro and in vivo research on the anti-inflammatory and antiapoptotic effects of HT and the mechanisms by which it works. Based on these studies, it is strongly advised to use HT as a bioactive ingredient in pharmaceutical products intended for mitigating inflammation, as well as those with apoptosis applications.
炎症和细胞凋亡是相互关联的生物学过程，对某些慢性疾病（如心血管问题、神经疾病和骨关节炎）的进展和发展有重大影响。最近的研究强调，关注这些机制可能会产生旨在降低疾病严重程度并改善患者预后的新治疗方法。以其抗氧化能力而闻名的羟基酪醇（HT）已被确定为调节炎症和细胞凋亡的潜在候选物。在这篇综述中，我们将强调HT作为治疗剂在减轻炎症、细胞凋亡及相关病症方面的多方面益处。这篇综述全面概述了关于HT抗炎和抗凋亡作用及其作用机制的最新体外和体内研究。基于这些研究，强烈建议将HT用作旨在减轻炎症的药品以及具有细胞凋亡应用的药品中的生物活性成分。
