Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Orthopedic Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
J Biochem Mol Toxicol. 2019 Sep;33(9):e22377. doi: 10.1002/jbt.22377. Epub 2019 Jul 23.
Hydroxytyrosol (HT), a primary phenolic antioxidant in olive oil, can afford protection from oxidative stress (OS) in different cells, including skin cells. In particular, it regulates several inflammation-associated processes as well as in improving the antioxidant defense system. However, there is no information about HT used in the treatment of hair loss. This work aimed at exploring the potential protective actions of HT against OS in rat dermal papilla cells. After treatment, the related expression of protein and messenger RNA were detected using morphological and molecular analyses. The results showed that HT significantly reduced intracellular reactive oxygen species level, apoptotic markers and inflammation induced by OS and enhanced cell survival by regulating autophagy. Furthermore, HT enhanced the secretion of hair growth factors in the anti-inflammation process. These results suggest that HT has a significant protective ability against OS and encourage the use of this biological ingredient as a possible tool to prevent alopecia.
羟基酪醇（HT）是橄榄油中的一种主要的酚类抗氧化剂，可在包括皮肤细胞在内的多种细胞中提供抗氧化应激（OS）保护。它可调节几种与炎症相关的过程，还可改善抗氧化防御系统。然而，目前尚无关于 HT 治疗脱发的信息。本研究旨在探索 HT 对 OS 作用于大鼠真皮乳头细胞的潜在保护作用。经处理后，采用形态学和分子分析检测蛋白和信使 RNA 的相关表达。结果表明，HT 可显著降低 OS 诱导的细胞内活性氧水平、凋亡标志物和炎症，通过调节自噬增强细胞存活。此外，HT 可增强抗炎过程中头发生长因子的分泌。这些结果表明 HT 对 OS 具有显著的保护能力，并鼓励将这种生物成分用作预防脱发的一种可能工具。
