Numerical Investigation of a Microfluidic Biosensor Based on I-Shaped Micropillar Array Electrodes.

Micropillar array electrodes offer several advantages, such as enhanced mass transport, lower detection limits, and the potential for miniaturization, making them instrumental in the design and fabrication of electrochemical biosensors. The performance of these biosensors is influenced by electrode geometry, including parameters like shape and height, which affect surface area and overall sensitivity. In this study, we designed a microfluidic electrochemical biosensor featuring micropillar array electrodes, modeled in COMSOL Multiphysics. We compared the response currents of I-shaped and cylindrical micropillar array electrodes. The working electrode (WE), consisting of 100 micropillars with a height of 300 µm, exhibited a sensitivity of 1.61 µA·cm·mM in cyclic voltammetry, highlighting its effectiveness for analyte detection.