Chang Iksoo, Chung Taegon, Kim Sangyeol
Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.
Creative Research Initiative Center for Proteome Biophysics, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.
Elife. 2025 Jan 8;13:RP99904. doi: 10.7554/eLife.99904.
Recent experimental studies showed that electrically coupled neural networks like in mammalian inferior olive nucleus generate synchronized rhythmic activity by the subthreshold sinusoidal-like oscillations of the membrane voltage. Understanding the basic mechanism and its implication of such phenomena in the nervous system bears fundamental importance and requires preemptively the connectome information of a given nervous system. Inspired by these necessities of developing a theoretical and computational model to this end and, however, in the absence of connectome information for the inferior olive nucleus, here we investigated interference phenomena of the subthreshold oscillations in the reference system for which the structural anatomical connectome was completely known recently. We evaluated how strongly the sinusoidal wave was transmitted between arbitrary two cells in the model network. The region of cell-pairs that are good at transmitting waves changed according to the wavenumber of the wave, for which we named a wavenumber-dependent transmission map. Also, we unraveled that (1) the transmission of all cell-pairs disappeared beyond a threshold wavenumber, (2) long distance and regular patterned transmission existed in the body-wall muscles part of the model network, and (3) major hub cell-pairs of the transmission were identified for many wavenumber conditions. A theoretical and computational model presented in this study provided fundamental insight for understanding how the multi-path constructive/destructive interference of the subthreshold oscillations propagating on electrically coupled neural networks could generate wavenumber-dependent synchronized rhythmic activity.
最近的实验研究表明，像哺乳动物下橄榄核中的电耦合神经网络通过膜电压的阈下类正弦振荡产生同步节律活动。理解这种现象在神经系统中的基本机制及其意义具有至关重要的意义，并且需要预先了解给定神经系统的连接组信息。受为此开发理论和计算模型的这些必要性的启发，然而，由于缺乏下橄榄核的连接组信息，我们在此研究了参考系统中阈下振荡的干涉现象，该参考系统的结构解剖连接组最近已完全清楚。我们评估了正弦波在模型网络中任意两个细胞之间的传输强度。善于传输波的细胞对区域根据波的波数而变化，为此我们将其命名为波数依赖传输图。此外，我们还揭示了：（1）所有细胞对的传输在超过阈值波数时消失；（2）在模型网络的体壁肌肉部分存在长距离和规则模式的传输；（3）在许多波数条件下确定了传输的主要枢纽细胞对。本研究中提出的理论和计算模型为理解在电耦合神经网络上传播的阈下振荡的多路径相长/相消干涉如何产生波数依赖的同步节律活动提供了基本见解。
