Foucar E, Bentley T J, Laube D W, Rosai J
Arch Dermatol. 1985 Mar;121(3):350-4.
A detailed histopathologic study was performed on 128 nevi removed from 86 pregnant white patients. None of the patients had clinical evidence of the dysplastic nevus syndrome, and none of the excised nevi were clinically suspicious for melanoma. One third of patients reported some change in nevi during pregnancy. Nevi from an age-matched male control population (50 patients) had a spectrum of histologic features essentially identical to the pregnant patients, while nevi from a female control population (51 patients) showed slightly less atypia according to our criteria. The differences found between the nevi from pregnant and control women suggest that a mild degree of histopathologic atypia or "activation" is associated with pregnancy. However, in the population studied, these changes were never of sufficient degree to result in diagnostic confusion.
对从86名白人孕妇身上切除的128颗痣进行了详细的组织病理学研究。所有患者均无发育异常痣综合征的临床证据，所有切除的痣在临床上均无黑色素瘤可疑迹象。三分之一的患者报告在怀孕期间痣有一些变化。年龄匹配的男性对照人群（50名患者）的痣具有一系列组织学特征，与孕妇基本相同，而根据我们的标准，女性对照人群（51名患者）的痣显示出稍少的异型性。孕妇和对照女性的痣之间发现的差异表明，轻度的组织病理学异型性或“激活”与妊娠有关。然而，在所研究的人群中，这些变化从未达到足以导致诊断混淆的程度。
