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Prophylactic cranial irradiation in small cell lung cancer: A review of evidence.小细胞肺癌的预防性颅脑照射：证据综述
J Biomed Res. 2025 Jan 25;39(2):1-4. doi: 10.7555/JBR.38.20240293.
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WITHDRAWN: Cranial irradiation for preventing brain metastases of small cell lung cancer in patients in complete remission.撤回：对完全缓解的小细胞肺癌患者进行颅脑照射以预防脑转移。
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Cranial irradiation for preventing brain metastases of small cell lung cancer in patients in complete remission.全脑照射预防完全缓解的小细胞肺癌患者发生脑转移。
Cochrane Database Syst Rev. 2000(4):CD002805. doi: 10.1002/14651858.CD002805.
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Prophylactic cranial irradiation for preventing brain metastases in patients undergoing radical treatment for non-small cell lung cancer.预防性颅脑照射用于预防接受非小细胞肺癌根治性治疗患者的脑转移。
Cochrane Database Syst Rev. 2005 Apr 18;2005(2):CD005221. doi: 10.1002/14651858.CD005221.
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Prophylactic cranial irradiation in small cell lung cancer: a systematic review of the literature with meta-analysis.小细胞肺癌的预防性颅脑照射：一项文献系统综述及荟萃分析
BMC Cancer. 2001;1:5. doi: 10.1186/1471-2407-1-5. Epub 2001 Jun 19.
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Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.用于预防和改善接受颅部放射治疗的成年人认知缺陷的干预措施。
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Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial.广泛期小细胞肺癌患者预防性颅脑照射与观察的比较：一项多中心、随机、开放标签、3 期临床试验。
Lancet Oncol. 2017 May;18(5):663-671. doi: 10.1016/S1470-2045(17)30230-9. Epub 2017 Mar 23.
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Hippocampal avoidance prophylactic cranial irradiation (HA-PCI) for small-cell lung cancer better preserves white matter networks compared to conventional PCI.与传统的预防性颅脑照射相比，小细胞肺癌的海马回避预防性颅脑照射（HA-PCI）能更好地保留白质网络。
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Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission.小细胞肺癌完全缓解患者的预防性颅脑照射。
J Natl Cancer Inst. 1995 Feb 1;87(3):183-90. doi: 10.1093/jnci/87.3.183.

本文引用的文献

1
PRIMALung (EORTC-1901): PRophylactic cerebral irradiation (PCI) or active brain MAgnetic resonance imaging (MRI) surveillance in small-cell lung cancer (SCLC) patients.原发性肺癌（EORTC-1901）：小细胞肺癌（SCLC）患者的预防性脑照射（PCI）或主动脑部磁共振成像（MRI）监测
Lung Cancer. 2024 Dec;198:107993. doi: 10.1016/j.lungcan.2024.107993. Epub 2024 Oct 24.
2
Re-examining prophylactic cranial irradiation in small cell lung cancer: a systematic review and meta-analysis.重新审视小细胞肺癌的预防性颅脑照射：一项系统评价和荟萃分析。
EClinicalMedicine. 2024 Jan 3;67:102396. doi: 10.1016/j.eclinm.2023.102396. eCollection 2024 Jan.
3
Phase II Trial of Atezolizumab Combined With Carboplatin and Pemetrexed for Patients With Advanced Nonsquamous Non-Small-Cell Lung Cancer With Untreated Brain Metastases (Atezo-Brain, GECP17/05).阿特珠单抗联合卡铂和培美曲塞治疗未经治疗的脑转移的晚期非鳞状非小细胞肺癌患者的 II 期临床试验（Atezo-Brain，GECP17/05）。
J Clin Oncol. 2023 Oct 1;41(28):4478-4485. doi: 10.1200/JCO.22.02561. Epub 2023 Aug 21.
4
A study of the prognosis of patients with limited-stage small cell lung cancer who did or did not receive prophylactic cranial irradiation after effective chemoradiotherapy.一项关于局限期小细胞肺癌患者在有效放化疗后接受或未接受预防性颅脑照射的预后研究。
Front Oncol. 2023 Mar 23;13:1118371. doi: 10.3389/fonc.2023.1118371. eCollection 2023.
5
Hippocampal avoidance prophylactic cranial irradiation (HA-PCI) for small cell lung cancer reduces hippocampal atrophy compared to conventional PCI.对于小细胞肺癌，与常规预防性颅脑照射（PCI）相比，海马回避预防性颅脑照射（HA-PCI）可减少海马萎缩。
Neuro Oncol. 2023 Jan 5;25(1):167-176. doi: 10.1093/neuonc/noac148.
6
Small Cell Lung Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.小细胞肺癌临床实践指南（2022 年版），NCCN 肿瘤学临床实践指南
J Natl Compr Canc Netw. 2021 Dec;19(12):1441-1464. doi: 10.6004/jnccn.2021.0058.
7
Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.更新后的副肿瘤性神经系统综合征诊断标准。
Neurol Neuroimmunol Neuroinflamm. 2021 May 18;8(4). doi: 10.1212/NXI.0000000000001014. Print 2021 Jul.
8
Small-cell lung cancer.小细胞肺癌。
Nat Rev Dis Primers. 2021 Jan 14;7(1):3. doi: 10.1038/s41572-020-00235-0.
9
Updated Overall Survival and PD-L1 Subgroup Analysis of Patients With Extensive-Stage Small-Cell Lung Cancer Treated With Atezolizumab, Carboplatin, and Etoposide (IMpower133).阿替利珠单抗联合卡铂和依托泊苷治疗广泛期小细胞肺癌患者的总生存更新和 PD-L1 亚组分析（IMpower133）。
J Clin Oncol. 2021 Feb 20;39(6):619-630. doi: 10.1200/JCO.20.01055. Epub 2021 Jan 13.
10
Neurological symptom burden impacts survival prognosis in patients with newly diagnosed non-small cell lung cancer brain metastases.新发非小细胞肺癌脑转移患者的神经症状负担影响生存预后。
Cancer. 2020 Oct 1;126(19):4341-4352. doi: 10.1002/cncr.33085. Epub 2020 Jul 17.

Prophylactic cranial irradiation in small cell lung cancer: A review of evidence.

作者信息

Adeoye Femi Williams

机构信息

Oncology Department, Southend University Hospital, Mid and South Essex NHS Foundation Trust, Prittlewell Chase, Southend-on-Sea, SS0 0RY, UK.

The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK.

出版信息

J Biomed Res. 2025 Jan 25;39(2):1-4. doi: 10.7555/JBR.38.20240293.

DOI:10.7555/JBR.38.20240293
PMID:39773855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11982683/
Abstract
摘要