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AL161431.1被鉴定为膀胱癌进展和免疫治疗反应的生物标志物。

AL161431.1 is identified as a biomarker for bladder cancer progression and immunotherapy response.

作者信息

Zhang Sihao, Wang Yaxuan, Han Zhenwei, Lu Baosai, Sun Kexin, Teng Zhihai, Jin Chenggen, Li Fang, Yuan Hao, Guo Fengran, Zhang Yanping

机构信息

Department of Urology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050011, China.

Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050011, China.

出版信息

Sci Rep. 2025 Jan 7;15(1):1170. doi: 10.1038/s41598-024-82425-4.

DOI:10.1038/s41598-024-82425-4
PMID:39774770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11706950/
Abstract

LncRNA AL161431.1 is currently known as a factor that can promote epithelial-mesenchymal transition. However, its role in the prognosis, immune infiltration and progression of bladder cancer (BLCA)patients is still unclear. The expression of AL161431.1 is elevated in BLCA tissues compared to normal tissues according to the TCGA database. By combining this data with clinical information, patients with high AL161431.1 expression have more advanced clinicopathological stages and shorter survival periods. Furthermore, AL161431.1 was identified as an independent prognostic factor for bladder cancer. We further analyzed the differences in immune infiltration, tumor mutation burden (TMB), immune checkpoints, and sensitivity to immunotherapy between groups with different levels of AL161431.1 expression. Enrichment analysis demonstrated that AL161431.1 is associated with numerous immune signaling pathways. High expression of AL161431.1 in cancer tissues was confirmed by qRT-PCR. CCK8, transwell, and wound healing demonstrated the oncogenic effects of AL161431.1. In conclusion, AL161431.1 is associated with immune infiltration in bladder cancer and has the potential to become a biomarker for predicting the prognosis of BLCA.

摘要

长链非编码RNA AL161431.1目前被认为是一种可促进上皮-间质转化的因子。然而，其在膀胱癌（BLCA）患者的预后、免疫浸润及病情进展中的作用仍不清楚。根据TCGA数据库，与正常组织相比，AL161431.1在BLCA组织中的表达升高。将该数据与临床信息相结合发现，AL161431.1高表达的患者具有更晚期的临床病理分期和更短的生存期。此外，AL161431.1被确定为膀胱癌的独立预后因素。我们进一步分析了不同AL161431.1表达水平组之间在免疫浸润、肿瘤突变负荷（TMB）、免疫检查点及免疫治疗敏感性方面的差异。富集分析表明，AL161431.1与众多免疫信号通路相关。通过qRT-PCR证实了癌组织中AL161431.1的高表达。CCK8、transwell和伤口愈合实验证明了AL161431.1的致癌作用。总之，AL161431.1与膀胱癌的免疫浸润相关，并且有潜力成为预测BLCA预后的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcb/11706950/390654876902/41598_2024_82425_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcb/11706950/db23d47dc66c/41598_2024_82425_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcb/11706950/6ce6e3114bbb/41598_2024_82425_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcb/11706950/989d980474b9/41598_2024_82425_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcb/11706950/655aa61ed47f/41598_2024_82425_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcb/11706950/68c7522089ff/41598_2024_82425_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcb/11706950/390654876902/41598_2024_82425_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcb/11706950/db23d47dc66c/41598_2024_82425_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcb/11706950/6ce6e3114bbb/41598_2024_82425_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcb/11706950/989d980474b9/41598_2024_82425_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcb/11706950/655aa61ed47f/41598_2024_82425_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcb/11706950/68c7522089ff/41598_2024_82425_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcb/11706950/390654876902/41598_2024_82425_Fig6_HTML.jpg

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Front Oncol. 2023 Jun 16;13:1134456. doi: 10.3389/fonc.2023.1134456. eCollection 2023.
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Bioinformatics construction and experimental validation of a cuproptosis-related lncRNA prognostic model in lung adenocarcinoma for immunotherapy response prediction.构建并实验验证肺腺癌中与铜死亡相关的 lncRNA 预后模型用于预测免疫治疗反应的生物信息学分析。
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Deciphering the map of METTL14-mediated lncRNA m6A modification at the transcriptome-wide level in breast cancer.
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Genetic variants of antioxidant enzymes and environmental exposures as molecular biomarkers associated with the risk and aggressiveness of bladder cancer.抗氧化酶的遗传变异和环境暴露作为与膀胱癌风险和侵袭性相关的分子生物标志物。
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