Julie Rigoureau, Yael Busnel, Anaïs Havet, Anne Termoz, Julie Haesebaert, Marie Viprey
Research on Healthcare Performance (RESHAPE), INSERM U1290, Université Claude Bernard Lyon 1, Lyon, France.
Hospices Civils de Lyon, Service Des Données de Santé, Lyon, France.
Pharmacoepidemiol Drug Saf. 2025 Jan;34(1):e70080. doi: 10.1002/pds.70080.
Patient and public involvement (PPI) in research is required to improve the relevance, feasibility, and interpretability. However, research on PPIs in pharmacoepidemiology (PE) is still limited. This study aimed to provide an overview of PPI implementation in pharmacoepidemiology through an environmental scan.
The environmental scan combined systematic reviews and expert interviews. A systematic review was conducted in MEDLINE, EMBASE, and the Cochrane Library from January 1, 2010, to June 30, 2023, to identify PE studies in which PPIs were mentioned. An additional review covered British Medical Journal's (BMJ) original articles from January 1, 2019, to June 30, 2023, via a similar method. In parallel, a cross-sectional study was conducted with a standardized questionnaire for French PE research teams, involving interviews via videoconference.
We identified 3615 references for screening, among which 232 were selected for full-text screening. However, no studies have reported the use of PPIs in PE studies. The additional BMJ review identified 1058 references, 74 of which met the full-text selection criteria, and eight were included. Of 13 French PE research teams surveyed, three had prior PPI experience, and 12 affirmed the relevance of PPI in PE. The respondents identified barriers such as PE's complexity (n = 9). They suggested training for patients (n = 9) and collaboration with specialist teams (n = 5) to facilitate PPI.
Our environmental scan highlighted the emergence and relevance of PPIs in PE studies, even though they are still uncommon. Tools are needed to acculture and assist PE researchers in engaging in PPIs.
研究中需要患者和公众参与（PPI）以提高研究的相关性、可行性和可解释性。然而，药物流行病学（PE）中关于PPI的研究仍然有限。本研究旨在通过环境扫描概述药物流行病学中PPI的实施情况。
环境扫描结合了系统评价和专家访谈。于2010年1月1日至2023年6月30日在MEDLINE、EMBASE和Cochrane图书馆进行系统评价，以识别提及PPI的PE研究。通过类似方法对英国医学杂志（BMJ）2019年1月1日至2023年6月30日的原创文章进行了额外的综述。同时，对法国PE研究团队进行了一项横断面研究，采用标准化问卷，通过视频会议进行访谈。
我们识别出3615篇供筛选的参考文献，其中232篇被选作全文筛选。然而，尚无研究报告在PE研究中使用PPI。BMJ的额外综述识别出1058篇参考文献，其中74篇符合全文选择标准，8篇被纳入。在接受调查的13个法国PE研究团队中，3个团队有PPI经验，12个团队肯定了PPI在PE中的相关性。受访者指出了PE的复杂性等障碍（n = 9）。他们建议对患者进行培训（n = 9）并与专业团队合作（n = 5）以促进PPI。
我们的环境扫描突出了PPI在PE研究中的出现及其相关性，尽管它们仍然不常见。需要工具来培养和协助PE研究人员参与PPI。
