Chung H, Hwang J M
Korean J Ophthalmol. 1989 Jun;3(1):1-5. doi: 10.3341/kjo.1989.3.1.1.
Cryotherapy is implicated for inducing or aggravating proliferative vitreoretinopathy (PVR) by releasing retinal pigment epithelial (RPE) cells. These are based on the fact that PVR rarely occurs in a non-operated eye, and many of the PVR patients have received cryotherapy during surgery. Nonetheless, eyes with diathermy also developed PVR, and although there have been many experiments, the effect of cryotherapy on inducing PVR has not been proven experimentally in the living eye. We made retinal tears in living rabbit eyes, and applied cryotherapy on one eye of each rabbit. The result was compared histologically with the contralateral noncryothermized control eye. There was no statistically significant difference between the two groups concerning the migration of RPE, and the proliferation of RPE. Although the formation of an epiretinal membrane was more obvious in the cryothermized group, the difference was not statistically significant.
冷冻疗法被认为会通过释放视网膜色素上皮（RPE）细胞来诱导或加重增殖性玻璃体视网膜病变（PVR）。这些观点基于以下事实：PVR很少发生在未手术的眼睛中，而且许多PVR患者在手术期间接受过冷冻疗法。尽管如此，接受透热疗法的眼睛也会发生PVR，并且尽管已经进行了许多实验，但冷冻疗法对诱导活体眼中PVR的影响尚未在实验中得到证实。我们在活体兔眼中制造视网膜裂孔，并对每只兔子的一只眼睛进行冷冻疗法。将结果与对侧未接受冷冻疗法的对照眼进行组织学比较。两组在RPE迁移和RPE增殖方面没有统计学上的显著差异。尽管在接受冷冻疗法的组中视网膜前膜的形成更明显，但差异没有统计学意义。
