Fadaei Mohammadmahdi, Lahijan Amirhossein Sangi Nasab, Jahanmehr Davood, Ahmadi Alireza, Asadi-Golshan Reza
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Nutr Neurosci. 2025 Aug;28(8):910-927. doi: 10.1080/1028415X.2024.2433257. Epub 2025 Jan 8.
This review examines how food additives impact the central nervous system (CNS) focusing on the effects of sugars, artificial sweeteners, colorings, and preservatives.
A literature search of PubMed, Scopus, and Web of Science was conducted for studies published since 2010. Key search terms included, food additives, neurotoxicity, cognition, and behavior.
It summarizes research findings on additives such as aspartame, stevia, methylene blue, azo dyes, sodium benzoate, and monosodium glutamate. It also covers mechanisms such as oxidative stress, neuroinflammation, and disruptions in neurotransmitter systems. Furthermore, it emphasizes the properties of natural compounds such as garlic (), tetramethylpyrazine, curcumin, licorice root extract (glycyrrhizin), and polyphenols in mitigating CNS damage caused by food additives.
Although ongoing studies are expanding our knowledge on the effects of these additives, future CNS research should focus on long-term investigations involving subjects to provide a more comprehensive understanding of the cumulative impacts of different additives and update regulatory standards based on new scientific findings.
本综述探讨食品添加剂如何影响中枢神经系统（CNS），重点关注糖、人工甜味剂、色素和防腐剂的影响。
对2010年以来发表的研究在PubMed、Scopus和科学网进行文献检索。关键检索词包括食品添加剂、神经毒性、认知和行为。
总结了关于阿斯巴甜、甜菊糖、亚甲蓝、偶氮染料、苯甲酸钠和味精等添加剂的研究结果。还涵盖了氧化应激、神经炎症和神经递质系统紊乱等机制。此外，强调了大蒜（）、川芎嗪、姜黄素、甘草根提取物（甘草酸）和多酚等天然化合物在减轻食品添加剂对中枢神经系统损害方面的特性。
尽管正在进行的研究正在扩展我们对这些添加剂影响的认识，但未来中枢神经系统研究应侧重于涉及受试者的长期调查，以便更全面地了解不同添加剂的累积影响，并根据新的科学发现更新监管标准。
