Chen Fen, Luo Jiao, Li Lin
Department of Paediatrics, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Department of Endocrinology and Nutrition, The Second Affiliated Hospital, Hengyang Medical School , University of South China, Hengyang, 421001, Hunan, China.
Osteoporos Int. 2025 Mar;36(3):485-500. doi: 10.1007/s00198-024-07349-1. Epub 2025 Jan 8.
According to the multivariable adjusted models, there was an inverse association between B-Cd levels and BMD, which was particularly evident in the subgroup analyses of other Hispanic and female individuals in the adolescent population. Clinicians and policy-makers should thoroughly consider the genetic implications of B-Cd levels in relation to BMD during the prevention and treatment of osteoporosis.
To investigate the associations between blood cadmium (B-Cd) levels and bone mineral density (BMD) in adolescents.
On the basis of the National Health and Nutrition Examination Survey (NHANES) database spanning from 2011 to 2018, we used weighted multiple regression, a generalized weighted model and smoothed curve methods to investigate the associations between B-Cd levels and BMD in adolescents. Subgroup analyses were also conducted to examine potential differences across age, sex, race, tobacco exposure status and other relevant variables.
Among the 2427 participants, 52% were males, and 48% were females. In this study, multistage sampling data from the NHANES database were analysed, and the positive association between B-Cd levels and BMD shifted to a negative association after adjustment for age, sex and race. Subgroup analyses revealed a more pronounced association among females (β = - 0.07, 95% CI: - 0.09, - 0.04, P < 0.001), other Hispanic individuals (β = - 0.08, 95% CI: - 0.14, - 0.02, P = 0.012) and individuals exposed to tobacco (β = - 0.04, 95% CI: - 0.06, - 0.01, P = 0.016).
The findings revealed a negative association between B-Cd levels and BMD in multivariable adjusted models.
根据多变量调整模型，血液镉（B-Cd）水平与骨密度（BMD）之间存在负相关，这在青少年人群中其他西班牙裔和女性个体的亚组分析中尤为明显。临床医生和政策制定者在骨质疏松症的预防和治疗过程中应充分考虑B-Cd水平与BMD的遗传关联。
研究青少年血液镉（B-Cd）水平与骨密度（BMD）之间的关联。
基于2011年至2018年的国家健康与营养检查调查（NHANES）数据库，我们使用加权多元回归、广义加权模型和平滑曲线方法来研究青少年B-Cd水平与BMD之间的关联。还进行了亚组分析，以检验年龄、性别、种族、烟草暴露状况和其他相关变量之间的潜在差异。
在2427名参与者中，52%为男性，48%为女性。在本研究中，对NHANES数据库的多阶段抽样数据进行了分析，在对年龄、性别和种族进行调整后，B-Cd水平与BMD之间的正相关转变为负相关。亚组分析显示，女性（β = -0.07，95%CI：-0.09，-0.04，P < 0.001）、其他西班牙裔个体（β = -0.08，95%CI：-0.14，-0.02，P = 0.012）和接触烟草的个体（β = -0.04，95%CI：-0.06，-0.01，P = 0.016）之间的关联更为显著。
研究结果显示，在多变量调整模型中，B-Cd水平与BMD之间存在负相关。
