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A blood test for Alzheimer's disease: a decade of progress and success.

作者信息

Ashton Nicholas J, Zetterberg Henrik

机构信息

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; Banner Alzheimer's Institute, Phoenix, AZ, USA; Banner Sun Health Research Institute, Sun City, AZ, USA.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, Institute of Neurology, UCL, London, UK; UK Dementia Research Institute, UCL, London, UK; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

出版信息

EBioMedicine. 2025 Feb;112:105545. doi: 10.1016/j.ebiom.2024.105545. Epub 2025 Jan 7.

DOI:10.1016/j.ebiom.2024.105545
PMID:39778288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11761914/
Abstract
摘要

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本文引用的文献

1
Detection and staging of Alzheimer's disease by plasma pTau217 on a high throughput immunoassay platform.基于高通量免疫分析平台的血浆 pTau217 检测和阿尔茨海默病分期。
EBioMedicine. 2024 Nov;109:105405. doi: 10.1016/j.ebiom.2024.105405. Epub 2024 Oct 21.
2
Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup.修订的阿尔茨海默病诊断和分期标准：阿尔茨海默病协会工作组。
Alzheimers Dement. 2024 Aug;20(8):5143-5169. doi: 10.1002/alz.13859. Epub 2024 Jun 27.
3
Head-to-Head Comparison of 8 Plasma Amyloid-β 42/40 Assays in Alzheimer Disease.阿尔茨海默病中 8 种血浆淀粉样蛋白β 42/40 分析物的对头比较。
JAMA Neurol. 2021 Nov 1;78(11):1375-1382. doi: 10.1001/jamaneurol.2021.3180.
4
High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis.高精度血浆β-淀粉样蛋白 42/40 可预测当前和未来的脑淀粉样变。
Neurology. 2019 Oct 22;93(17):e1647-e1659. doi: 10.1212/WNL.0000000000008081. Epub 2019 Aug 1.
5
Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography.血浆磷酸化 tau181 随着阿尔茨海默病临床严重程度的增加而增加，与 tau 和淀粉样蛋白正电子发射断层扫描相关。
Alzheimers Dement. 2018 Aug;14(8):989-997. doi: 10.1016/j.jalz.2018.02.013. Epub 2018 Apr 5.
6
A Decade of Blood Biomarkers for Alzheimer's Disease Research: An Evolving Field, Improving Study Designs, and the Challenge of Replication.阿尔茨海默病研究的十年血液生物标志物：一个不断发展的领域，改进研究设计，以及复制的挑战。
J Alzheimers Dis. 2018;62(3):1181-1198. doi: 10.3233/JAD-170531.
7
Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer's disease and down syndrome.定量检测血浆磷酸化 tau 作为脑内阿尔茨海默病病理标志物的研究：包括阿尔茨海默病患者和唐氏综合征患者的初步病例对照研究。
Mol Neurodegener. 2017 Sep 4;12(1):63. doi: 10.1186/s13024-017-0206-8.
8
Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study.血浆神经丝轻蛋白（NFL）浓度是 HIV 感染中枢神经系统损伤的生物标志物：一项横断面研究。
EBioMedicine. 2015 Nov 22;3:135-140. doi: 10.1016/j.ebiom.2015.11.036. eCollection 2016 Jan.
9
Plasma proteins predict conversion to dementia from prodromal disease.血浆蛋白可预测前驱疾病向痴呆症的转化。
Alzheimers Dement. 2014 Nov;10(6):799-807.e2. doi: 10.1016/j.jalz.2014.05.1749. Epub 2014 Jul 8.
10
Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations.单分子酶联免疫吸附测定法可检测纳飞摩尔浓度级别的血清蛋白。
Nat Biotechnol. 2010 Jun;28(6):595-9. doi: 10.1038/nbt.1641. Epub 2010 May 23.