血浆蛋白可预测前驱疾病向痴呆症的转化。
Plasma proteins predict conversion to dementia from prodromal disease.
作者信息
Hye Abdul, Riddoch-Contreras Joanna, Baird Alison L, Ashton Nicholas J, Bazenet Chantal, Leung Rufina, Westman Eric, Simmons Andrew, Dobson Richard, Sattlecker Martina, Lupton Michelle, Lunnon Katie, Keohane Aoife, Ward Malcolm, Pike Ian, Zucht Hans Dieter, Pepin Danielle, Zheng Wei, Tunnicliffe Alan, Richardson Jill, Gauthier Serge, Soininen Hilkka, Kłoszewska Iwona, Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Lovestone Simon
机构信息
Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK.
Institute of Psychiatry, Department of Old Age Psychiatry, King's College London, London, UK; Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
出版信息
Alzheimers Dement. 2014 Nov;10(6):799-807.e2. doi: 10.1016/j.jalz.2014.05.1749. Epub 2014 Jul 8.
BACKGROUND
The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia.
METHODS
Three multicenter cohorts of cognitively healthy elderly, mild cognitive impairment (MCI), and AD participants with standardized clinical assessments and structural neuroimaging measures were used. Twenty-six candidate proteins were quantified in 1148 subjects using multiplex (xMAP) assays.
RESULTS
Sixteen proteins correlated with disease severity and cognitive decline. Strongest associations were in the MCI group with a panel of 10 proteins predicting progression to AD (accuracy 87%, sensitivity 85%, and specificity 88%).
CONCLUSIONS
We have identified 10 plasma proteins strongly associated with disease severity and disease progression. Such markers may be useful for patient selection for clinical trials and assessment of patients with predisease subjective memory complaints.
背景
本研究旨在验证先前发现的与阿尔茨海默病（AD）相关的血浆生物标志物，采用基于成像测量作为疾病严重程度替代指标的设计，并评估其在预测向痴呆症转化方面的预后价值。
方法
使用了三个多中心队列，包括认知健康的老年人、轻度认知障碍（MCI）患者以及患有AD且经过标准化临床评估和结构神经成像测量的参与者。使用多重（xMAP）检测法对1148名受试者中的26种候选蛋白进行了定量分析。
结果
16种蛋白与疾病严重程度和认知衰退相关。最强的关联出现在MCI组，一组10种蛋白可预测向AD的进展（准确率87%，敏感性85%，特异性88%）。
结论
我们已经确定了10种与疾病严重程度和疾病进展密切相关的血浆蛋白。这些标志物可能有助于临床试验的患者选择以及对有疾病前期主观记忆主诉的患者进行评估。
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