Kampeerapappun Piyaporn, Desclaux Scarlett, Rattanapinyopituk Kasem, Srisuk Tanyalak, Hemstapat Ruedee
Faculty of Textile Industries, Rajamangala University of Technology Krungthep, Bangkok, 10120, Thailand.
Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Sci Rep. 2025 Jan 8;15(1):1291. doi: 10.1038/s41598-025-85886-3.
Sutures from natural and synthetic materials are utilized to close wounds, stop bleeding, reduce pain and infection, repair cutaneous wounds, minimize scarring, and promote optimal wound healing. We used mechanical and chemical methods to extract cellulose fibers from cylindrical snake grass (Dracaena angolensis) (Welw. ex Carrière) Byng & Christenh. Following the extraction process, the fibers increased in cellulose and water content, while hemicellulose and lignin decreased. The extracted fibers exhibited good mechanical properties, with weight losses of 7.4% in deionized water (DI) and 13.7% in phosphate-buffered saline (PBS). In comparison, the commercial braided silk sutures (Mersilk braided silk non-absorbable suture) used as a control showed no weight loss. However, the morphology of the fibers remained consistent throughout the 35-day immersion period in either DI or PBS. In an in vivo biocompatibility test, a semi-quantitative analysis of host tissue reactions indicated no significant difference (p > 0.05) between the two suturing materials across all criteria, confirming the comparable biocompatibility of cylindrical snake grass fibers to that of commercial silk sutures. These findings demonstrate the promising potential of natural cellulose fibers derived from cylindrical snake grass as an alternative source of a non-absorbable surgical suture biomaterial, attributed to their outstanding mechanical properties and biocompatibility.
天然和合成材料制成的缝线用于闭合伤口、止血、减轻疼痛和感染、修复皮肤伤口、减少疤痕形成并促进伤口的最佳愈合。我们采用机械和化学方法从圆筒蛇草（Dracaena angolensis）（韦尔威氏草，卡里埃命名，拜恩和克里斯滕森修订）中提取纤维素纤维。提取过程之后，纤维的纤维素和水分含量增加，而半纤维素和木质素含量减少。提取的纤维表现出良好的机械性能，在去离子水中重量损失7.4%，在磷酸盐缓冲盐水中重量损失13.7%。相比之下，用作对照的商业编织丝线（Mersilk编织非吸收性丝线）没有重量损失。然而，在去离子水或磷酸盐缓冲盐水中浸泡35天的整个期间，纤维的形态保持一致。在体内生物相容性测试中，对宿主组织反应的半定量分析表明，两种缝合材料在所有标准上均无显著差异（p＞0.05），证实圆筒蛇草纤维与商业丝线具有相当的生物相容性。这些发现表明，源自圆筒蛇草的天然纤维素纤维作为不可吸收手术缝合生物材料的替代来源具有广阔的潜力，这归因于其出色的机械性能和生物相容性。
