Department of Biofibers and Biomaterials Science, Kyungpook National University, Daegu 41566, Republic of Korea.
Preclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea.
Int J Mol Sci. 2023 Sep 29;24(19):14750. doi: 10.3390/ijms241914750.
Recently, nonwoven fabrics from natural silk have attracted considerable attention for biomedical and cosmetic applications because of their good mechanical properties and cytocompatibility. Although these fabrics can be easily fabricated using the binding character of sericin, the high cost of silk material may restrict its industrial use in certain areas. In this study, sericin was added as a binder to a cheaper material (wool) to prepare wool-based nonwoven fabrics and investigate the effect of the amount of sericin added on the structural characteristics and properties of the wool nonwoven fabric. It was found using SEM that sericin coated the surface of wool fibers and filled the space between them. With an increase in sericin addition, the porosity, moisture regain, and the contact angle of the sericin-coated wool nonwoven fabric decreased. The maximum stress and initial Young's modulus of the nonwoven fabric increased with the increase in sericin amount up to 32.5%, and decreased with a further increase in the amount of sericin. Elongation at the end steadily decreased with the increase in sericin addition. All of the nonwoven fabrics showed good cytocompatibility, which increased with the amount of sericin added. These results indicate that sericin-coated wool-based nonwoven fabrics may be successfully prepared by adding sericin to wool fibers, and that the properties of these fabrics may be diversely controlled by altering the amount of sericin added, making them promising candidates for biomedical and cosmetic applications.
最近，由于天然丝的非织造布具有良好的机械性能和细胞相容性，因此在生物医学和化妆品应用中引起了相当大的关注。尽管这些织物可以很容易地使用丝胶的结合特性来制造，但是丝材料的高成本可能会限制其在某些领域的工业应用。在这项研究中，丝胶被添加到一种更便宜的材料（羊毛）中作为粘合剂，以制备羊毛基非织造布，并研究添加丝胶的量对羊毛非织造布的结构特征和性能的影响。SEM 发现丝胶涂覆在羊毛纤维的表面并填充了它们之间的空间。随着丝胶添加量的增加，非织造布的孔隙率、回潮率和接触角降低。非织造布的最大应力和初始杨氏模量随着丝胶量的增加而增加，在丝胶量增加 32.5%时达到最大值，然后随着丝胶量的进一步增加而降低。伸长率随着丝胶添加量的增加而稳定下降。所有的非织造布都表现出良好的细胞相容性，随着丝胶添加量的增加而增加。这些结果表明，通过向羊毛纤维中添加丝胶，可以成功制备丝胶涂覆的羊毛基非织造布，并且可以通过改变丝胶添加量来多样化控制这些织物的性能，使它们成为生物医学和化妆品应用的有前途的候选材料。
