Wang Zhehui, Valnohova Jana, Kolesnichenko Kirill, Baba Akira, Sun Hong, Mao Xin, Kryuchkov Mikhail, Katanaev Vladimir L
School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong 271016, China.
Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Rue Michel Servet 1, Geneva CH-1211, Switzerland.
ACS Appl Bio Mater. 2025 Jan 20;8(1):784-791. doi: 10.1021/acsabm.4c01620. Epub 2025 Jan 8.
Moth-eye nanostructures, known for their biological antireflective properties, are formed by a self-assembly mechanism. Understanding and replicating this mechanism on artificial surfaces open avenues for the engineering of bioinspired multifunctional nanomaterials. Analysis of corneal nanocoatings from butterflies of the genus reveals a variety of nanostructures with uniformly strong antiwetting properties accompanied by varying antireflective functionalities. Interestingly, while the structural features of the nanocoatings determine the antireflective functionality, the antiwetting is controlled by their chemical composition, an unusual trait among insects. The availability of whole-genome sequences for several species allowed us to identify the corneal proteome, including the protein responsible for the nanocoating assembly, CPR67A. The high hydrophobicity of this protein, coupled with its capacity to mediate self-assembly, underlies the formation of unique multifunctional nanostructures and permits the development of bioinspired artificial nanocoatings. Our findings pave the way for biomimetic nanomaterials and guide the engineering of nanostructures with predefined functionalities.
蛾眼纳米结构以其生物抗反射特性而闻名，它是通过自组装机制形成的。在人工表面理解并复制这一机制为仿生多功能纳米材料的工程化开辟了道路。对 属蝴蝶角膜纳米涂层的分析揭示了多种具有均匀强抗湿性能且伴有不同抗反射功能的纳米结构。有趣的是，虽然纳米涂层的结构特征决定抗反射功能，但抗湿性由其化学成分控制，这在昆虫中是一个不寻常的特征。几种 物种全基因组序列的可得性使我们能够鉴定角膜蛋白质组，包括负责纳米涂层组装的蛋白质CPR67A。这种蛋白质的高疏水性及其介导自组装的能力，是独特的多功能 纳米结构形成的基础，并允许开发仿生人工纳米涂层。我们的发现为仿生纳米材料铺平了道路，并指导具有预定义功能的纳米结构的工程化。
