Rizk Mohamed, El-Alamin Maha Mahmoud Abou, Elkhalek Ola Abd, Hendawy Hassan A M
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Helwan University, P.O.Box 11795, Cairo, Egypt.
National Organization for Drug Control and Research (NODCAR), P.O.Box 29, Cairo, Egypt.
BMC Chem. 2025 Jan 8;19(1):9. doi: 10.1186/s13065-024-01358-1.
Tirofiban hydrochloride is used to inhibit platelet aggregation, which has a significant impact on the treatment of congestive heart failure the most common cause of death according to WHO. Therefore, its quantification in pharmaceutical dosage form is critical. In this work, an electrochemical method for the determination of tirofiban HCl in pharmaceutical dosage form was developed and validated. Carbon paste electrode modified with multi-walled carbon nanotubes (MWCNT) was utilized to examine the electrochemical response of tirofiban hydrochloride. Scanning electron microscopy and Energy-dispersive X-ray analysis was used to investigate the morphology of this electrode. A linear response was obtained within the range of (27.00-745.00 ng/mL) (5.4 × 10 M-1.5 × 10 M) with a correlation coefficient of 0.9995, and a detection limit of 15.50 ng/mL (3.1 × 10 M). The greenness profile of the method was assessed utilizing the eco-scale and the green analytical procedure Index.
盐酸替罗非班用于抑制血小板聚集，这对治疗充血性心力衰竭有重大影响，据世界卫生组织称，充血性心力衰竭是最常见的死亡原因。因此，对其在药物剂型中的定量分析至关重要。在这项工作中，开发并验证了一种用于测定药物剂型中盐酸替罗非班的电化学方法。利用多壁碳纳米管（MWCNT）修饰的碳糊电极来检测盐酸替罗非班的电化学响应。使用扫描电子显微镜和能量色散X射线分析来研究该电极的形态。在（27.00 - 745.00 ng/mL）（5.4×10⁻⁸ M - 1.5×10⁻⁷ M）范围内获得线性响应，相关系数为0.9995，检测限为15.50 ng/mL（3.1×10⁻⁸ M）。利用生态规模和绿色分析程序指数评估了该方法的绿色度概况。
