噻吗洛尔滴眼液进入人房水的情况：最初一小时
Penetration of timolol eye drops into human aqueous humour: the first hour.
作者信息
Phillips C I, Bartholomew R S, Levy A M, Grove J, Vogel R
出版信息
Br J Ophthalmol. 1985 Mar;69(3):217-8. doi: 10.1136/bjo.69.3.217.
Abstract
Samples of aqueous humour were removed from 26 eyes at the start of cataract extraction. Two drops of timolol 0.5% had been instilled into the conjunctival sac 12-71 minutes before operation. Analysis by gas chromatography showed a mean timolol concentration of 55.46 ng/mg, with a range of 8 to 100 ng/mg.
摘要
在白内障摘除手术开始时，从26只眼睛中采集了房水样本。术前12 - 71分钟，已在结膜囊中滴入两滴0.5%的噻吗洛尔。气相色谱分析显示，噻吗洛尔的平均浓度为55.46纳克/毫克，范围为8至100纳克/毫克。
相似文献
1
Penetration of timolol eye drops into human aqueous humour: the first hour.噻吗洛尔滴眼液进入人房水的情况：最初一小时
Br J Ophthalmol. 1985 Mar;69(3):217-8. doi: 10.1136/bjo.69.3.217.
2
Penetration of timolol eye drops into human aqueous humour.噻吗洛尔滴眼液在人房水中的渗透情况。
Br J Ophthalmol. 1981 Sep;65(9):593-5. doi: 10.1136/bjo.65.9.593.
3
Concentration of timolol in aqueous humour.房水中噻吗洛尔的浓度。
Doc Ophthalmol. 1991;78(3-4):255-8. doi: 10.1007/BF00165688.
4
Absorption of ocular timolol: drug concentrations and beta-receptor binding activity in the aqueous humour of the treated and contralateral eye.
Acta Ophthalmol (Copenh). 1993 Oct;71(5):671-6. doi: 10.1111/j.1755-3768.1993.tb04659.x.
5
Plasma and aqueous humour concentrations and systemic effects of topical betaxolol and timolol in man.噻吗洛尔和倍他洛尔局部应用于人时的血浆及房水浓度和全身效应
Acta Ophthalmol (Copenh). 1993 Apr;71(2):201-6. doi: 10.1111/j.1755-3768.1993.tb04991.x.
6
Ophthalmic timolol in a hydrogel vehicle leads to minor inter-individual variation in timolol concentration in aqueous humor.水凝胶载体中的眼科用噻吗洛尔导致房水中噻吗洛尔浓度存在较小的个体间差异。
Eur J Pharm Sci. 2009 Feb 15;36(2-3):292-6. doi: 10.1016/j.ejps.2008.10.004. Epub 2008 Nov 1.
7
Influence of the concentration of metipranolol eye drops on the drug concentration in human aqueous humour.
Graefes Arch Clin Exp Ophthalmol. 1991;229(5):487-91. doi: 10.1007/BF00166315.
8
Effect of nasolacrimal occlusion on timolol concentrations in the aqueous humor of the human eye.鼻泪管阻塞对人眼房水中噻吗洛尔浓度的影响。
J Pharm Sci. 1992 Mar;81(3):219-20. doi: 10.1002/jps.2600810305.
9
Influence of the strength, drop size and viscosity of metipranolol eye drops on the concentration of the substance in human aqueous humour.
Graefes Arch Clin Exp Ophthalmol. 1991;229(5):452-6. doi: 10.1007/BF00166309.
10
Penetration of topically applied betamethasone sodium phosphate into human aqueous humour.局部应用的倍他米松磷酸钠在人房水中的渗透情况。
Eye (Lond). 1990;4 ( Pt 4):603-6. doi: 10.1038/eye.1990.84.
引用本文的文献
1
Penetration of nadolol into aqueous humour after a single oral dose.单次口服给药后纳多洛尔在房水中的渗透情况。
Br J Clin Pharmacol. 1988 Jul;26(1):92-5. doi: 10.1111/j.1365-2125.1988.tb03369.x.
2
Concentration of timolol in aqueous humour.房水中噻吗洛尔的浓度。
Doc Ophthalmol. 1991;78(3-4):255-8. doi: 10.1007/BF00165688.
3
Influence of the concentration of metipranolol eye drops on the drug concentration in human aqueous humour.
Graefes Arch Clin Exp Ophthalmol. 1991;229(5):487-91. doi: 10.1007/BF00166315.
4
Influence of the strength, drop size and viscosity of metipranolol eye drops on the concentration of the substance in human aqueous humour.
Graefes Arch Clin Exp Ophthalmol. 1991;229(5):452-6. doi: 10.1007/BF00166309.
本文引用的文献
1
Penetration of timolol into the rabbit eye. Measurements after ocular instillation and intravenous injection.
Arch Ophthalmol. 1980 Mar;98(3):547-51. doi: 10.1001/archopht.1980.01020030543023.
2
Penetration of timolol eye drops into human aqueous humour.噻吗洛尔滴眼液在人房水中的渗透情况。
Br J Ophthalmol. 1981 Sep;65(9):593-5. doi: 10.1136/bjo.65.9.593.
3
Penetration of five beta-adrenergic antagonists into the rabbit eye after ocular instillation.眼内滴注后五种β-肾上腺素能拮抗剂在兔眼中的渗透情况。
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;217(3):167-74. doi: 10.1007/BF00411147.
4
Ocular penetration of beta-adrenergic blocking agents. An experimental study with atenolol, metoprolol, timolol and propranolol.β-肾上腺素能阻滞剂的眼内渗透。阿替洛尔、美托洛尔、噻吗洛尔和普萘洛尔的实验研究。
Doc Ophthalmol. 1980 Apr 15;48(2):291-301. doi: 10.1007/BF00141456.
5
Electron-capture GLC determination of timolol in human plasma and urine.
J Pharm Sci. 1975 Nov;64(11):1879-81. doi: 10.1002/jps.2600641130.
6
Penetration of atenolol in the rabbit eye.
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Nov 30;208(4):235-40. doi: 10.1007/BF00419378.
Zotero 插件