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噻吗洛尔滴眼液进入人房水的情况：最初一小时

Penetration of timolol eye drops into human aqueous humour: the first hour.

作者信息

Phillips C I, Bartholomew R S, Levy A M, Grove J, Vogel R

出版信息

Br J Ophthalmol. 1985 Mar;69(3):217-8. doi: 10.1136/bjo.69.3.217.

DOI:10.1136/bjo.69.3.217
PMID:3978068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1040566/
Abstract

Samples of aqueous humour were removed from 26 eyes at the start of cataract extraction. Two drops of timolol 0.5% had been instilled into the conjunctival sac 12-71 minutes before operation. Analysis by gas chromatography showed a mean timolol concentration of 55.46 ng/mg, with a range of 8 to 100 ng/mg.

摘要

在白内障摘除手术开始时，从26只眼睛中采集了房水样本。术前12 - 71分钟，已在结膜囊中滴入两滴0.5%的噻吗洛尔。气相色谱分析显示，噻吗洛尔的平均浓度为55.46纳克/毫克，范围为8至100纳克/毫克。

相似文献

1
Penetration of timolol eye drops into human aqueous humour: the first hour.噻吗洛尔滴眼液进入人房水的情况：最初一小时
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2
Penetration of timolol eye drops into human aqueous humour.噻吗洛尔滴眼液在人房水中的渗透情况。
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引用本文的文献

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Br J Clin Pharmacol. 1988 Jul;26(1):92-5. doi: 10.1111/j.1365-2125.1988.tb03369.x.
2
Concentration of timolol in aqueous humour.房水中噻吗洛尔的浓度。
Doc Ophthalmol. 1991;78(3-4):255-8. doi: 10.1007/BF00165688.
3
Influence of the concentration of metipranolol eye drops on the drug concentration in human aqueous humour.
Graefes Arch Clin Exp Ophthalmol. 1991;229(5):487-91. doi: 10.1007/BF00166315.
4
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本文引用的文献

1
Penetration of timolol into the rabbit eye. Measurements after ocular instillation and intravenous injection.
Arch Ophthalmol. 1980 Mar;98(3):547-51. doi: 10.1001/archopht.1980.01020030543023.
2
Penetration of timolol eye drops into human aqueous humour.噻吗洛尔滴眼液在人房水中的渗透情况。
Br J Ophthalmol. 1981 Sep;65(9):593-5. doi: 10.1136/bjo.65.9.593.
3
Penetration of five beta-adrenergic antagonists into the rabbit eye after ocular instillation.眼内滴注后五种β-肾上腺素能拮抗剂在兔眼中的渗透情况。
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;217(3):167-74. doi: 10.1007/BF00411147.
4
Ocular penetration of beta-adrenergic blocking agents. An experimental study with atenolol, metoprolol, timolol and propranolol.β-肾上腺素能阻滞剂的眼内渗透。阿替洛尔、美托洛尔、噻吗洛尔和普萘洛尔的实验研究。
Doc Ophthalmol. 1980 Apr 15;48(2):291-301. doi: 10.1007/BF00141456.
5
Electron-capture GLC determination of timolol in human plasma and urine.
J Pharm Sci. 1975 Nov;64(11):1879-81. doi: 10.1002/jps.2600641130.
6
Penetration of atenolol in the rabbit eye.
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Nov 30;208(4):235-40. doi: 10.1007/BF00419378.