Li Guanyang, Xu Junfei, Li Huanhuan, Yan Wenxin, Chen Fengting, Yuan Anwen, Zhang Juzuo
Department of Clinic Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
College of Biological and Food Engineering/Key Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province/Hunan Provincial Higher Education Key Laboratory of Intensive Processing Research on Mountain Ecological Food, Huaihua University, Huaihua 418000, China.
J Poult Sci. 2025 Jan 8;62:2025002. doi: 10.2141/jpsa.2025002. eCollection 2025.
Avian gout (AG) is detrimental to the survival and production performance of poultry and effective drugs are lacking. has shown clinical efficacy against arthritis and may have potential value in AG prevention and treatment. In the present study, the components and targets of and AG-related targets were identified using relevant databases. The common targets, target interactions, and signaling pathways involved in the prevention and treatment of AG by were determined using software to explore the potential mechanisms of action. Sixteen components of , eight of which were active ingredients with 351 targets and 2993 AG-related targets, were identified using several databases. A total of 156 common targets were associated with 202 biological processes and 34 pathways. Toll-like receptor 4 (TLR4) and prostaglandin endoperoxide synthase 2 were core targets. These targets may exert therapeutic effects on AG through four pathways: the nucleotide-binding oligomerization domain (NOD)-like receptor, mammalian target of rapamycin, TLR, and mitogen-activated protein kinase signaling pathways. In summary, has potential therapeutic efficacy against AG through multicomponent, multi-target, and multi-pathway mechanisms.
禽痛风（AG）对家禽的生存和生产性能有害，且缺乏有效的药物。[具体药物名称未给出]已显示出对关节炎的临床疗效，并且可能在AG的预防和治疗中具有潜在价值。在本研究中，使用相关数据库鉴定了[具体药物名称未给出]的成分和靶点以及AG相关靶点。使用软件确定了[具体药物名称未给出]预防和治疗AG所涉及的共同靶点、靶点相互作用和信号通路，以探索其潜在作用机制。通过多个数据库鉴定出[具体药物名称未给出]的16种成分，其中8种为活性成分，有351个靶点和2993个AG相关靶点。共有156个共同靶点与202个生物学过程和34条信号通路相关。Toll样受体4（TLR4）和前列腺素内过氧化物合酶2是核心靶点。这些靶点可能通过四种途径对AG发挥治疗作用：核苷酸结合寡聚化结构域（NOD）样受体、雷帕霉素哺乳动物靶点、TLR和丝裂原活化蛋白激酶信号通路。总之，[具体药物名称未给出]通过多成分、多靶点和多途径机制对AG具有潜在治疗效果。
