Girolami A, Procidano M, Vicariotto M, Cappellato G, Vicari T
Blut. 1985 Mar;50(3):141-8. doi: 10.1007/BF00320070.
The behavior of the prothrombin complex factors in 16 healthy women during low-dose estroprogestinic treatment (laevonorgestrel 0.15 mg and ethynilestradiol 0.30 mg) at basal conditions and during 8 months of therapy has been investigated. We found a statistically significant decrease of the PTT (Partial Thromboplastin Time). The prothrombin time, on the other hand, became slightly decreased, but not to a statistically significant extent. Among the prothrombin time derived tests for evaluating the prothrombin complex only the PP test (Prothrombin Proconvertin test) was significantly shortened. Of the coagulation factors (factors II, VII and X) only a modest, but not statistically significant, increase in Factor VII and Factor X was noted. We conclude that, during the 8 month observation period, prothrombin complex factors are not altered substantially.
对16名健康女性在低剂量雌孕激素治疗（左炔诺孕酮0.15毫克和炔雌醇0.30毫克）基础状态及治疗8个月期间凝血酶原复合物因子的行为进行了研究。我们发现部分凝血活酶时间（PTT）有统计学意义的下降。另一方面，凝血酶原时间略有下降，但未达到统计学显著程度。在用于评估凝血酶原复合物的凝血酶原时间衍生检测中，只有凝血酶原促转化素试验（PP试验）显著缩短。在凝血因子（因子II、VII和X）中，仅观察到因子VII和因子X有适度增加，但无统计学意义。我们得出结论，在8个月的观察期内，凝血酶原复合物因子没有实质性改变。
