Dixon J M, Scott W N, Miller W R
Br J Surg. 1985 Mar;72(3):190-2. doi: 10.1002/bjs.1800720311.
All breast cysts aspirated from a series of 100 patients followed for a minimum period of 2 years were classified on the basis of electrolyte composition as apocrine or flattened, this being the nature of the epithelium lining the two populations of breast cysts. Patients with a single cyst were more than 3 times as likely to have a flattened rather than an apocrine cyst. Multiple cysts, whether simultaneous or sequential in any individual patient, were usually all of the same type, and were more commonly apocrine than flattened. A comparison of the frequency of subsequent cysts in patients whose initial cysts were of either apocrine or flattened type showed further cysts were over 5 times more common in patients who presented with apocrine cysts. These observations suggest that the natural history of cystic disease is closely related to cyst type.
对100例患者随访至少2年期间抽取的所有乳腺囊肿，根据电解质成分分为大汗腺型或扁平型，这是两种乳腺囊肿内衬上皮的性质。单个囊肿的患者出现扁平型囊肿而非大汗腺型囊肿的可能性是前者的3倍多。多个囊肿，无论在任何个体患者中是同时出现还是先后出现，通常都属于同一类型，且大汗腺型比扁平型更常见。对初始囊肿为大汗腺型或扁平型的患者后续囊肿出现频率进行比较，结果显示出现大汗腺型囊肿的患者中出现进一步囊肿的情况比前者多5倍以上。这些观察结果表明，囊性疾病的自然病程与囊肿类型密切相关。
