Leenders K L, Wolfson L, Gibbs J M, Wise R J, Causon R, Jones T, Legg N J
Brain. 1985 Mar;108 ( Pt 1):171-91. doi: 10.1093/brain/108.1.171.
Studies performed on 18 patients with Parkinson's disease and 6 control subjects have shown that acute administration of L-DOPA in clinically effective doses gives rise to a diffuse increase in regional cerebral blood flow without accompanying stimulation of regional oxygen utilization. The data suggest that this rise in rCBF is caused by vasodilatation due to a direct action of the drug on the cerebral blood vessels. The effect of L-DOPA on rCBF did not correlate with the degree of clinical improvement seen in each patient after treatment. The therapeutic effect of L-DOPA in the brain was not reflected in any change of regional cerebral oxygen utilization as measured by our technique. We suggest that the pharmacological actions of L-DOPA in the brain take place on at least two different levels.
对18名帕金森病患者和6名对照受试者进行的研究表明，以临床有效剂量急性给予左旋多巴会导致局部脑血流量普遍增加，而不会伴随局部氧利用的刺激。数据表明，这种局部脑血流量的增加是由药物对脑血管的直接作用导致血管舒张引起的。左旋多巴对局部脑血流量的影响与治疗后每位患者的临床改善程度无关。我们的技术测量结果显示，左旋多巴在大脑中的治疗效果并未反映在局部脑氧利用的任何变化上。我们认为，左旋多巴在大脑中的药理作用至少发生在两个不同层面。
