Lipkin M, Uehara K, Winawer S, Sanchez A, Bauer C, Phillips R, Lynch H T, Blattner W A, Fraumeni J F
Cancer Lett. 1985 Mar;26(2):139-44. doi: 10.1016/0304-3835(85)90019-9.
The proliferation of epithelial cells in colonic mucosa was studied in humans at varying degrees of risk for colon cancer. Seventh-Day Adventist vegetarians, known to have significantly lower mortality from colon cancer than the general U.S. population, had the most quiescent proliferative activity of mucosal epithelial cells. Increased replication and expansion of the proliferative compartment accompanied increased colon cancer risk. The analytical methods of this study may be useful in assessing the influence of dietary components involved in the initiation, promotion or inhibition of colon cancer, and in developing strategies for nutritional intervention.
在患结肠癌风险程度不同的人群中，对结肠黏膜上皮细胞的增殖情况进行了研究。已知基督复临安息日会素食者患结肠癌的死亡率显著低于美国普通人群，他们黏膜上皮细胞的增殖活性最为静止。增殖区室的复制和扩张增加伴随着患结肠癌风险的增加。本研究的分析方法可能有助于评估饮食成分在结肠癌起始、促进或抑制过程中的影响，以及制定营养干预策略。
