利用直肠黏膜隐窝细胞产生率（CCPR）鉴定结直肠癌的高风险和低风险群体。
The identification of high and low risk groups for colorectal cancer using rectal mucosal crypt cell production rate (CCPR).
作者信息
Rooney P S, Clarke P A, Gifford K A, Hardcastle J D, Armitage N C
机构信息
Department of Surgery, University Hospital, Nottingham, UK.
出版信息
Br J Cancer. 1993 Jul;68(1):172-5. doi: 10.1038/bjc.1993.308.
Rectal mucosal proliferation was measured in 116 individuals using the metaphase arrest technique crypt cell production rate (CCPR). CCPR was found to be significantly elevated in individuals with adenomas (n = 42, CCPR = 13 cc c-1h-1, range 7-25 Cl 10-15) compared with normals (n = 21, CCPR = 10 cc c-1h-1 range 5-24 Cl 7-11, Mann-Whitney P = 0.001 z = 3.2). Mucosal proliferation was increased among individuals who were undergoing adenoma follow up but in whom no further adenomas were found (n = 37 CCPR = 12 range 5-26 cc c-1h-1 Cl 10-14) compared to controls (Mann-Whitney P = 0.01 z = 2.4) Proliferation in vegetarians i.e. low risk (n = 16) was similar to controls. Measurement of proliferative indices in rectal mucosa by the stathmokinetic technique CCPR can discriminate between high and low risk groups for colorectal cancer.
采用中期阻断技术隐窝细胞产生率（CCPR）对116名个体的直肠黏膜增殖情况进行了测量。结果发现，与正常个体（n = 21，CCPR = 10 cc c-1h-1，范围5 - 24，可信区间7 - 11，Mann-Whitney检验P = 0.001，z = 3.2）相比，腺瘤患者（n = 42，CCPR = 13 cc c-1h-1，范围7 - 25，可信区间10 - 15）的CCPR显著升高。在接受腺瘤随访但未发现新腺瘤的个体中（n = 37，CCPR = 12，范围5 - 26 cc c-1h-1，可信区间10 - 14），黏膜增殖较对照组增加（Mann-Whitney检验P = 0.01，z = 2.4）。素食者（即低风险人群，n = 16）的增殖情况与对照组相似。通过静止动力学技术CCPR测量直肠黏膜增殖指数，可区分结直肠癌的高风险和低风险组。
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