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胶原蛋白α-1(x)基因表达在人类癌症中的特征及其治疗意义。

Signature of collagen alpha-1(x) gene expression in human cancers and their therapeutic implications.

作者信息

Nagarajan Akshaya, Varadhan Varsha, Manikandan Monica Shri, Kaliaperumal Kumaravel, Palaniyandi Thirunavukkarasu, Kaliamoorthy Senthilkumar, Baskar Gomathy, Rab Safia Obaidur, Balaramnavar Vishal M, Kumarasamy Saravanan

机构信息

Department of Biotechnology, Dr. M. G. R Educational and Research Institute, Chennai, Tamil Nadu 600095, India.

Department of Orthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India.

出版信息

Pathol Res Pract. 2025 Feb;266:155811. doi: 10.1016/j.prp.2025.155811. Epub 2025 Jan 3.

Abstract

Cancers are a class of disorders that entail uncontrollably unwanted cell development with dissemination. One in six fatalities globally is attributed to cancer, a global health issue. The analysis of the entire DNA sequence and how it expresses itself in tumor cells is known as cancer genomics. The development of novel cancer treatments has been facilitated because of the genomics method. COL10A1 gene, a short chain collagen, and an interstitial matrix component, acts as a predictive biomarker for cancer prognosis. Recognizing the fundamental consequences of mutations in the COL10A1 gene and its expression in cancer is crucial. Analyzing the COL10A1 gene expression with a data set and gene expression patterns shows the level of display of the tumor. Examining the therapeutic techniques of COL10A1 gene expression leads to early detection, screening, radiation therapy, and advanced developments. This review highlights the value of the COL10A1 gene in breast, gastric, pancreatic, lung, and colorectal cancers, emphasizing its role in gene expression patterns and therapeutic techniques.

摘要

癌症是一类涉及细胞不受控制地异常生长并扩散的疾病。全球六分之一的死亡归因于癌症,这是一个全球性的健康问题。对整个DNA序列及其在肿瘤细胞中的表达方式进行分析被称为癌症基因组学。基因组学方法推动了新型癌症治疗方法的发展。COL10A1基因是一种短链胶原蛋白,也是一种间质基质成分,可作为癌症预后的预测生物标志物。认识到COL10A1基因突变的基本后果及其在癌症中的表达至关重要。通过数据集和基因表达模式分析COL10A1基因表达可显示肿瘤的表现水平。研究COL10A1基因表达的治疗技术有助于早期检测、筛查、放射治疗及进一步发展。本综述强调了COL10A1基因在乳腺癌、胃癌、胰腺癌、肺癌和结直肠癌中的价值,着重阐述了其在基因表达模式和治疗技术中的作用。

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