Kim Yeonjeong, Kim Sung Eun, Park Ki Dong, Park Kyung Min
Department of Bioengineering and Nano-Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Republic of Korea.
Department of Molecular Science and Technology, Ajou University, 5 Woncheon, Yeongtong, Suwon 443-749, Republic of Korea.
J Control Release. 2025 Mar 10;379:285-302. doi: 10.1016/j.jconrel.2025.01.015. Epub 2025 Jan 13.
Delayed wound healing remains a major challenge in biomedical research, often leading to complications such as scarring, acute trauma, and chronic diseases. Effective wound management is crucial for enhancing treatment outcomes, preventing complications, and promoting tissue regeneration. In response to this need, a variety of polymeric biomaterials have been developed. A growing focus in the field involves the design of bioadhesives and bioactive materials, which offer promising solutions for wound management. Recent advances in materials engineering have led to the development of polymer biomaterials with excellent biocompatibility, strong adhesion to biological surfaces, and bioactive properties that support rapid wound closure and tissue repair. This review discusses the latest progress in the development and application of bioadhesives and bioactive hydrogels for wound management and tissue regeneration, highlighting potential directions for future biomaterial research.
伤口愈合延迟仍然是生物医学研究中的一项重大挑战，常常会引发诸如瘢痕形成、急性创伤和慢性疾病等并发症。有效的伤口处理对于提高治疗效果、预防并发症以及促进组织再生至关重要。为满足这一需求，人们开发了多种聚合物生物材料。该领域越来越关注生物粘合剂和生物活性材料的设计，它们为伤口处理提供了有前景的解决方案。材料工程学的最新进展已促使具有优异生物相容性、对生物表面有强粘附力以及具备支持伤口快速闭合和组织修复的生物活性特性的聚合物生物材料得以发展。本综述讨论了用于伤口处理和组织再生的生物粘合剂和生物活性水凝胶在开发与应用方面的最新进展，突出了未来生物材料研究的潜在方向。
