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青鳉的主要雄性性别决定基因Gdf6Y是通过等位基因新功能化产生的。

The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization.

作者信息

Richter Annekatrin, Mörl Hanna, Thielemann Maria, Kleemann Markus, Geißen Raphael, Schwarz Robert, Albertz Carolin, Koch Philipp, Petzold Andreas, Kroll Torsten, Groth Marco, Hartmann Nils, Herpin Amaury, Englert Christoph

机构信息

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany.

BianoGMP GmbH, Gera, Germany.

出版信息

Nat Commun. 2025 Jan 9;16(1):540. doi: 10.1038/s41467-025-55899-7.

DOI:10.1038/s41467-025-55899-7
PMID:39788971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11718055/
Abstract

Although sex determination is a fundamental process in vertebrate development, it is very plastic. Diverse genes became major sex determinants in teleost fishes. Deciphering how individual sex-determining genes orchestrate sex determination can reveal new actors in sexual development. Here, we demonstrate that the Y-chromosomal copy of the TGF-β family member gdf6 (gdf6Y) in Nothobranchius furzeri, an emerging model organism in aging research, gained the function of the male sex determinant through allelic diversification while retaining the skeletal developmental function shared with the X-chromosomal gdf6 allele (gdf6X). Concerning sex determination, gdf6Y is expressed by somatic supporting cells of the developing testes. There it induces the male sex in a germ cell-independent manner in contrast to sex determination in zebrafish and the medaka. Looking for downstream effectors of Gdf6Y, we identified besides TGF-β signaling modulators, especially the inhibitor of DNA binding genes id1/2/3, the mRNA decay activator zfp36l2 as a new GDF6 signaling target.

摘要

尽管性别决定是脊椎动物发育中的一个基本过程，但它具有很强的可塑性。多种基因成为硬骨鱼类的主要性别决定因素。解读单个性别决定基因如何协调性别决定，能够揭示性发育中的新参与者。在这里，我们证明，在衰老研究中的新兴模式生物——非洲青鳉中，转化生长因子-β（TGF-β）家族成员gdf6的Y染色体拷贝（gdf6Y），通过等位基因多样化获得了雄性性别决定功能，同时保留了与X染色体gdf6等位基因（gdf6X）共有的骨骼发育功能。关于性别决定，gdf6Y由发育中的睾丸的体细胞支持细胞表达。在那里，它以一种不依赖生殖细胞的方式诱导雄性性别，这与斑马鱼和青鳉中的性别决定不同。在寻找Gdf6Y的下游效应子时，我们发现，除了TGF-β信号调节剂，特别是DNA结合基因id1/2/3的抑制剂外，mRNA衰变激活因子zfp36l2是一个新的GDF6信号靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75db/11718055/066ef1977ecf/41467_2025_55899_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75db/11718055/4a200a22cb9b/41467_2025_55899_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75db/11718055/a3b03c378ea4/41467_2025_55899_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75db/11718055/463118d5388a/41467_2025_55899_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75db/11718055/060b9e320131/41467_2025_55899_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75db/11718055/3a67fa4025a1/41467_2025_55899_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75db/11718055/066ef1977ecf/41467_2025_55899_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75db/11718055/4a200a22cb9b/41467_2025_55899_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75db/11718055/a3b03c378ea4/41467_2025_55899_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75db/11718055/463118d5388a/41467_2025_55899_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75db/11718055/060b9e320131/41467_2025_55899_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75db/11718055/3a67fa4025a1/41467_2025_55899_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75db/11718055/066ef1977ecf/41467_2025_55899_Fig6_HTML.jpg

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