2021年至2024年中国香港特别行政区高致病性禽流感病毒（H5N1/H5N8）2.3.4.4b分支的检测与特征分析
Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024.
作者信息
Sun Wanying, Choy Ka Tim, Cheng Ka Man, Brackman Christopher J, Cheng Samuel Ms, Sit Thomas Hc, Tse Anne Cn, Sims Leslie D, Gu Haogao, Tang Amy Wy, Wong Andrew Nc, Tsang Andrew Tl, Koo Joe Ct, Luk Leo Lh, Yen Hui-Ling, Peris Malik, Poon Leo Lm
机构信息
School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region (Hong Kong SAR), China.
Government of the Hong Kong Special Administrative Region (HKSARG), Hong Kong SAR, China.
出版信息
Euro Surveill. 2025 Jan;30(1). doi: 10.2807/1560-7917.ES.2025.30.1.2400839.
We isolated three genotypes of highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b from wild birds infected with H5N1 (n = 12) and H5N8 (n = 1) in Hong Kong SAR 2021-2024. Viruses from two spoonbills from late 2022 were genetically related to a virus from a human in China. Four tested viruses exhibited variable virulence in mice but were susceptible to approved antivirals. No neutralising antibody was detected in 63 age-stratified human sera, suggesting potential risk should the virus adapt to humans.
2021年至2024年期间，我们从香港特别行政区感染H5N1（n = 12）和H5N8（n = 1）的野生鸟类中分离出三种高致病性禽流感病毒（HPAIV）2.3.4.4b基因型。2022年末从两只琵鹭身上分离出的病毒在基因上与中国一名人类身上的病毒相关。四种测试病毒在小鼠中表现出不同的毒力，但对批准使用的抗病毒药物敏感。在63份按年龄分层的人类血清中未检测到中和抗体，这表明该病毒若适应人类可能存在潜在风险。
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