Vanle Brigitte, Beatty Timothy
Trident Medical Center, Charleston, SC.
HCA Healthc J Med. 2024 Dec 1;5(6):739-743. doi: 10.36518/2689-0216.1738. eCollection 2024.
Nitrofurantoin is a prevalent antibiotic used to treat urinary tract infections. Despite nitrofurantoin's general safety, it can cause serious side effects, including acute pulmonary toxicity, fulminant hepatitis, and severe systemic inflammatory responses, which may mimic conditions such as ischemia and infection. However, reports of acute systemic inflammatory response syndrome after nitrofurantoin ingestion are uncommon in medical literature.
This case describes a severe systemic inflammatory response syndrome in an 85-year-old woman presenting with hypoxia, altered mental status, and profound leukocytosis after exposure to a single dose of nitrofurantoin.
Herein we report on a patient with suspected bacteremia and urosepsis. Who was treated with broad-spectrum antibiotics. However, the antibiotic used to treat the patient's urinary tract infection caused an altered mental status and systemic inflammatory response. Therefore, it is crucial for clinicians to consider iatrogenic and medication-induced etiologies for altered mental status.
呋喃妥因是一种用于治疗尿路感染的常用抗生素。尽管呋喃妥因总体安全，但它可引起严重副作用，包括急性肺毒性、暴发性肝炎和严重的全身炎症反应，这些反应可能类似于缺血和感染等情况。然而，呋喃妥因摄入后急性全身炎症反应综合征的报告在医学文献中并不常见。
本病例描述了一名85岁女性在单次服用呋喃妥因后出现严重全身炎症反应综合征，表现为缺氧、精神状态改变和显著的白细胞增多。
在此我们报告一名疑似菌血症和尿脓毒症的患者。该患者接受了广谱抗生素治疗。然而，用于治疗患者尿路感染的抗生素导致了精神状态改变和全身炎症反应。因此，临床医生考虑精神状态改变的医源性和药物性病因至关重要。
