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Systemic inflammatory response syndrome (SIRS) and a left bundle branch block (LBBB) due to nitrofurantoin.由呋喃妥因引起的全身炎症反应综合征（SIRS）和左束支传导阻滞（LBBB）。
BMJ Case Rep. 2017 May 22;2017:bcr-2016-218127. doi: 10.1136/bcr-2016-218127.
2
[Pulmonary toxicity resulting from the use of nitrofurantoin].[使用呋喃妥因导致的肺毒性]
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Nitrofurantoin neuropathy: a forgotten adverse effect.呋喃妥因神经病变：一种被遗忘的不良反应。
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[Liver cirrhosis due to chronic use of nitrofurantoin].慢性使用呋喃妥因导致的肝硬化
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Nitrofurantoin and pregnancy.呋喃妥因与妊娠
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[Safety of nitrofurantoin in pregnancy].[呋喃妥因在孕期的安全性]
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Rare adverse effect of a common drug: nitrofurantoin-induced ANCA-associated vasculitis.一种常见药物的罕见不良反应：呋喃妥因诱发的抗中性粒细胞胞浆抗体相关性血管炎。
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[Nitrofurantoin--clinical relevance in uncomplicated urinary tract infections].[呋喃妥因——在单纯性尿路感染中的临床意义]
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Agranulocytosis associated with nitrofurantoin therapy.
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Evaluation of a Patient With a Severe Systemic Inflammatory Response to Nitrofurantoin.对一名对呋喃妥因产生严重全身炎症反应患者的评估
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Systemic Inflammatory Response Syndrome from Nitrofurantoin: A Case Report.硝呋太尔引起的全身炎症反应综合征：1 例报告。
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Systemic Inflammatory Response Syndrome Secondary to Nitrofurantoin.继发于呋喃妥因的全身炎症反应综合征。
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本文引用的文献

1
Ineffectiveness and adverse events of nitrofurantoin in women with urinary tract infection and renal impairment in primary care.在初级保健中，患有尿路感染和肾功能损害的女性中使用呋喃妥因的无效性和不良反应。
Eur J Clin Pharmacol. 2013 Sep;69(9):1701-7. doi: 10.1007/s00228-013-1520-x. Epub 2013 May 10.
2
International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases.国际临床实践指南：女性急性单纯性膀胱炎和肾盂肾炎的治疗（2010 年更新）：美国传染病学会和欧洲临床微生物学和传染病学会。
Clin Infect Dis. 2011 Mar 1;52(5):e103-20. doi: 10.1093/cid/ciq257.
3
Nitrofurantoin-induced systemic inflammatory response syndrome.呋喃妥因诱发的全身炎症反应综合征
Am J Med Sci. 2009 Oct;338(4):338-40. doi: 10.1097/MAJ.0b013e3181abd9f6.
4
A method for estimating the probability of adverse drug reactions.一种估算药物不良反应概率的方法。
Clin Pharmacol Ther. 1981 Aug;30(2):239-45. doi: 10.1038/clpt.1981.154.

由呋喃妥因引起的全身炎症反应综合征（SIRS）和左束支传导阻滞（LBBB）。

Systemic inflammatory response syndrome (SIRS) and a left bundle branch block (LBBB) due to nitrofurantoin.

作者信息

Gandotra Susheer Dilbagh, Smotrys Mariola A, Patel Darshan B, Chadha Akash

机构信息

Infectious Diseases, Pocono Medical Center, East Stroudsburg, Pennsylvania, USA.

Sacred Heart Hospital, Allentown, Pennsylvania, USA.

出版信息

BMJ Case Rep. 2017 May 22;2017:bcr-2016-218127. doi: 10.1136/bcr-2016-218127.

DOI:10.1136/bcr-2016-218127
PMID:28536210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5753713/
Abstract

We present a case of a 74-year-old woman, who was on nitrofurantoin treatment for urinary tract infection (UTI), with fever and chills 7 hours after taking nitrofurantoin. She was hospitalised and evaluated for worsening UTI and sepsis. Initially, it appeared to be secondary to post-UTI sepsis because of possible resistant infection or conditions like pulmonary embolism or acute hepatitis. The patient also developed systemic inflammatory response syndrome, left bundle branch block (LBBB), thrombocytopaenia and transaminitis. Considering the side effects of nitrofurantoin, it was stopped. The patient showed improvement and recovered completely with symptomatic and supportive treatment. During follow-up visits with her primary care physician, thrombocytopaenia, transaminitisandLBBB were found to have been resolved.

摘要

我们报告一例74岁女性病例，该患者因尿路感染接受呋喃妥因治疗，服用呋喃妥因7小时后出现发热和寒战。她因尿路感染恶化和脓毒症入院接受评估。最初，这似乎继发于尿路感染后的脓毒症，原因可能是耐药感染或肺栓塞、急性肝炎等情况。患者还出现了全身炎症反应综合征、左束支传导阻滞（LBBB）、血小板减少和转氨酶升高。考虑到呋喃妥因的副作用，停用了该药。患者经对症和支持治疗后症状改善并完全康复。在她的初级保健医生的随访中，发现血小板减少、转氨酶升高和左束支传导阻滞已得到缓解。