Rodgers B M, Pappelis P
Cryobiology. 1985 Feb;22(1):86-92. doi: 10.1016/0011-2240(85)90011-2.
Studies are reported to define the tolerance of the feline esophagus to cryoinjury. Thirty-seven cats underwent endoesophageal cryotherapy to temperatures of -100, -120, -140 degrees C for 30 sec. Animals were sacrificed at 90 min, 4, 10, 14, and 20 days. The extent of cryoinjury was evaluated with ciné esophagogram, esophageal manometrics, and pathologic evaluation. Esophagograms demonstrated mural edema, coinciding with diminished amplitude of peristalsis in the area of freeze. All animals frozen to -100 degrees C survived with complete healing. Of the animals frozen to -120 and -140 degrees C, 14 and 15%, respectively, developed esophageal perforation. The feline esophagus tolerates local freezing to levels of -100 degrees C with complete healing. This modality may be useful in treating superficial lesions of the esophagus.
有研究报道旨在确定猫食管对冷冻损伤的耐受性。37只猫接受食管内冷冻治疗，温度分别为-100℃、-120℃、-140℃，持续30秒。在90分钟、4天、10天、14天和20天时对动物实施安乐死。通过食管电影造影、食管测压和病理评估来评价冷冻损伤的程度。食管造影显示壁层水肿，与冷冻区域蠕动幅度减小相一致。所有冷冻至-100℃的动物均存活且完全愈合。冷冻至-120℃和-140℃的动物中，分别有14%和15%发生食管穿孔。猫食管能耐受局部冷冻至-100℃的程度并完全愈合。这种方法可能对治疗食管浅表病变有用。
