Clinical Epidemiology Resource and Training Centre (CERTC), Medical College, Thiruvananthapuram, Kerala, India.
Indian Pediatr. 2012 Jan;49(1):17-9. doi: 10.1007/s13312-012-0008-6. Epub 2011 May 30.
To study the role of iron deficiency as a risk factor for simple febrile seizures.
Case control study.
Pediatric department of a tertiary care teaching hospital.
154 cases and 154 controls were included in the study. Consecutive cases and concurrent controls were selected. Cases were children of age group 6 months to 3 years presenting with simple febrile seizures. Controls were children of same age group presenting with short febrile illness but without any seizures.
After informed consent, detailed history was taken and clinical examination done in both cases and controls and blood investigations were done to diagnose iron-deficiency in both cases and controls. Iron deficiency was diagnosed as per WHO criteria (hemoglobin value <11 g%, red cell distribution width of >15% and serum ferritin value <12 ng/mL). Other explanatory variables, which can be the potential confounders were also included in the study and considered for analysis.
Highly significant association was found between iron deficiency and simple febrile seizures in both univariate and multivariate analysis. Crude odds ratio was 5.34 (CI 3.27- 8.73, P<0.001) and adjusted odds ratio in the logistic regression analysis was 4.5 (CI 2.69- 7.53, P <0.001).
Iron deficiency is a significant risk factor for simple febrile seizures in children of age group 6 months to 3 years.
研究缺铁作为单纯性热性惊厥危险因素的作用。
病例对照研究。
三级教学医院儿科。
本研究纳入了 154 例病例和 154 例对照。连续选择病例和同期对照。病例为年龄在 6 个月至 3 岁之间、伴有单纯性热性惊厥的儿童。对照为年龄相同、有短期发热性疾病但无任何惊厥的儿童。
在获得知情同意后，对病例和对照均进行详细病史采集和临床检查，并进行血液检查以诊断病例和对照的缺铁情况。根据世界卫生组织（WHO）标准（血红蛋白值<11 g%，红细胞分布宽度>15%，血清铁蛋白值<12 ng/mL）诊断缺铁。还纳入了其他可能的混杂变量作为解释变量，并进行了分析。
单因素和多因素分析均显示，缺铁与单纯性热性惊厥之间存在显著关联。粗比值比为 5.34（95%可信区间为 3.27-8.73，P<0.001），logistic 回归分析中的调整比值比为 4.5（95%可信区间为 2.69-7.53，P<0.001）。
缺铁是 6 个月至 3 岁儿童单纯性热性惊厥的一个重要危险因素。
