Momeni Sarieh, Ghorbani-Vaghei Ramin
Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University, Hamedan, Iran.
Sci Rep. 2024 Sep 15;14(1):21531. doi: 10.1038/s41598-024-71461-9.
This study aimed to create an innovative acidic nano catalyst capable of producing pyrimido[4,5-b]quinolines under environmentally friendly conditions. To achieve this objective, 1,3-benzenedisulfonyl amide (BDSA) was immobilized onto the surface of magnetic graphene oxide (GO/FeO@PTRMS@BDSA@SOH), and its surface was acidified using chlorosulfonic acid. The synthesized catalyst's structure was thoroughly examined and verified through various analyses, including FTIR, EDX, elemental mapping, FESEM, XRD, TGA, and DSC. This novel nano catalyst exhibited exceptional activity and selectivity in synthesizing pyrimido[4,5-b]quinoline derivatives under solvent-free conditions, at low temperatures, and with high efficiency. Its catalytic effectiveness stemmed from features such as easy and eco-friendly synthesis methods, abundant accessible catalytic sites, a high surface area, remarkable selectivity, and facile separation from the reaction medium. Additionally, the catalyst proved to be cost-effective, safe, scalable, and reusable for up to four times.
本研究旨在制备一种创新的酸性纳米催化剂，该催化剂能够在环境友好的条件下合成嘧啶并[4,5-b]喹啉。为实现这一目标，将1,3-苯二磺酰胺（BDSA）固定在磁性氧化石墨烯表面（GO/FeO@PTRMS@BDSA@SOH），并用氯磺酸对其表面进行酸化。通过傅里叶变换红外光谱（FTIR）、能谱分析（EDX）、元素映射、场发射扫描电子显微镜（FESEM）、X射线衍射（XRD）、热重分析（TGA）和差示扫描量热法（DSC）等各种分析方法，对合成催化剂的结构进行了全面研究和验证。这种新型纳米催化剂在无溶剂条件下、低温且高效地合成嘧啶并[4,5-b]喹啉衍生物时表现出优异的活性和选择性。其催化效果源于合成方法简便且环保、可利用的催化位点丰富、比表面积高、选择性显著以及易于从反应介质中分离等特点。此外，该催化剂具有成本效益、安全、可扩展且可重复使用多达四次。
