Gona O, Gorelli L
Curr Eye Res. 1985 Jan;4(1):59-63. doi: 10.3109/02713688508999968.
We have investigated the effect of the anterior pituitary hormone, prolactin, on mitosis in the lens epithelium of the galactose-fed rat. Our findings indicate that prolactin had a stimulatory effect on galactose-triggered mitosis within 24 hours after hormone administration. After three full days of galactose-feeding and daily prolactin injections, lens epithelia from prolactin treated rats had fewer mitoses than those from saline-injected controls. At the time when the number of mitoses had fallen to a subnormal level due to galactose-feeding (i.e., after 7 days), lenses of prolactin-treated animals exhibited less of a decrease in mitotic activity. Thus, it seems that prolactin modulates the mitotic response of lens epithelial cells when animals are on a galactose-rich diet. This modulation may be due, among other things, to a general acceleration of the cataractogenic process, mediated by the osmoregulatory action of prolactin.
我们研究了垂体前叶激素催乳素对喂食半乳糖的大鼠晶状体上皮细胞有丝分裂的影响。我们的研究结果表明，在给予激素后的24小时内，催乳素对半乳糖引发的有丝分裂有刺激作用。在连续三天喂食半乳糖并每日注射催乳素后，接受催乳素治疗的大鼠的晶状体上皮细胞的有丝分裂比注射生理盐水的对照组少。当由于喂食半乳糖导致有丝分裂数量降至正常水平以下时（即7天后），接受催乳素治疗的动物的晶状体有丝分裂活性的降低幅度较小。因此，当动物食用富含半乳糖的饮食时，催乳素似乎会调节晶状体上皮细胞的有丝分裂反应。这种调节可能部分归因于催乳素的渗透调节作用介导的致白内障过程的普遍加速。
