Toukan A U, Kamal M F, Amr S S, Arnaout M A, Abu-Romiyeh A S
Dig Dis Sci. 1985 Apr;30(4):313-20. doi: 10.1007/BF01403839.
Proper control and quantitation are important in the accurate evaluation of gastroduodenal inflammation in dyspeptic patients without ulcers or erosions as proved by endoscopy. The endoscopic findings and the gastroduodenal mucosal inflammatory cell count in 31 patients with non-ulcer dyspepsia were compared with an age-matched group of 32 healthy controls. Endoscopy revealed similar mucosal changes and in similar frequency in both groups. Differential mucosal inflammatory cell count showed a statistically significant (P less than 0.001) increase in the neutrophil count in the gastric body, antrum, and duodenal cap of the dyspeptic group, as well as a slight but significant (P less than 0.05) increase in the round cell and eosinophil count of the duodenal mucosa alone. No correlation was found between the endoscopic changes and an increase in neutrophil count above a normal level determined by the healthy controls. However, an endoscopically normal mucosa was more likely to be associated with a normal neutrophil count. Active inflammation of the gastroduodenal mucosa likely accounts for the symptoms in patients with non-ulcer dyspepsia.
在内镜检查证实无溃疡或糜烂的消化不良患者中，恰当的对照和定量对于准确评估胃十二指肠炎症至关重要。将31例非溃疡性消化不良患者的内镜检查结果和胃十二指肠黏膜炎症细胞计数与32例年龄匹配的健康对照者进行比较。内镜检查显示两组的黏膜变化相似且频率相近。差异黏膜炎症细胞计数显示，消化不良组胃体、胃窦和十二指肠球部的中性粒细胞计数有统计学意义的显著增加（P<0.001），仅十二指肠黏膜的圆形细胞和嗜酸性粒细胞计数有轻微但显著的增加（P<0.05）。在内镜检查变化与高于健康对照者确定的正常水平的中性粒细胞计数增加之间未发现相关性。然而，内镜检查正常的黏膜更可能与正常的中性粒细胞计数相关。胃十二指肠黏膜的活动性炎症可能是导致非溃疡性消化不良患者出现症状的原因。
