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[利用3型牛腺病毒诱导小鼠培养细胞恶性转化及MNNG对该过程的修饰]

[Malignant transformation of mouse cultured cells using bovine adenovirus type 3 and modification of this process by MNNG].

作者信息

Lukash L L, Kononenko L I, Buzhievskaia T I, Bykorez A I, Shapiro N I

出版信息

Eksp Onkol. 1984;6(5):33-5.

PMID:6510341
Abstract

It is shown that tumour transformation of cultured mouse cells 10T1/2C3H depends on the time after the infection with virus BAV-3. The maximal number of tumours was observed 3 weeks after infection, then the frequency of tumours was reduced. MNNG modified virus-induced tumour cell transformation differently depending on the time between cell infection and treatment with the chemical agent.

摘要

结果表明，培养的小鼠细胞10T1/2C3H的肿瘤转化取决于感染病毒BAV-3后的时间。感染后3周观察到肿瘤数量最多，随后肿瘤发生频率降低。根据细胞感染与化学试剂处理之间的时间不同，MNNG对病毒诱导的肿瘤细胞转化有不同的影响。

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