Gus'kova T A, Liberman S S
Farmakol Toksikol. 1985 Jan-Feb;48(1):80-2.
It has been established in rat experiments that toxicity of the antibacterial drug dioxydin (1,4-di-N-oxide 2,3-dioxymethylquinoxaline) depends on the time of administration. The drug exhibits the minimal and maximal toxicity upon administration at 8 o'clock p.m. and at 12 o'clock, respectively.
