Shashkina L F, Ivanova V M, Lavrik O I, Proĭnova V A, Nechushkina L V
Farmakol Toksikol. 1985 Jan-Feb;48(1):77-80.
A study was made of the blastomogenic activity of dioxydin, a new antibacterial broad-action drug. Administration of dioxydin in doses of 20-100 mg/kg (exceeding 2-10-fold the therapeutic dose for humans) to mice and rats intragastrically for 18 months and intraperitoneally (2 years of observation) as well as combined administration of the drug to rats transplacentally and postnatally (1.5 years of observation) did not induce any neoplasms.
对新型广谱抗菌药物二氧啶的致瘤活性进行了一项研究。以20 - 100毫克/千克的剂量（超过人类治疗剂量的2 - 10倍）给小鼠和大鼠灌胃18个月、腹腔注射（观察2年），以及对大鼠进行经胎盘和产后联合给药（观察1.5年），均未诱发任何肿瘤。
