Piper D W, McIntosh J H, Hudson H M
Digestion. 1985;31(1):9-16. doi: 10.1159/000199171.
The aim of the study was to define the effects of sex, age, smoking, alcohol, analgesic ingestion, and treatment method whereby healing was initially induced on the prognosis of patients with a chronic duodenal ulcer (DU). 122 patients were assessed 1 year after the endoscopic demonstration of a DU. Two outcome variables for this 1-year period were studied - freedom from symptoms, and proven recurrence of the DU. Additionally, the outcome groups were compared to a community control population as regards the exposure variables. The results of the study indicate that each increase in smoking by 10 cigarettes daily increased the risk of DU recurrence within 1 year by 40%. Comparisons between patients and community controls revealed that smoking was significantly associated with DU and this association was present whether the ulcer was in exacerbation or in remission.
本研究的目的是确定性别、年龄、吸烟、饮酒、服用镇痛药以及最初诱导愈合的治疗方法对慢性十二指肠溃疡（DU）患者预后的影响。在内镜检查证实患有DU后1年，对122例患者进行了评估。研究了这1年期间的两个结果变量——无症状以及DU的确诊复发。此外，就暴露变量而言，将结果组与社区对照人群进行了比较。研究结果表明，每天吸烟量每增加10支，1年内DU复发的风险就增加40%。患者与社区对照之间的比较显示，吸烟与DU显著相关，无论溃疡处于加重期还是缓解期，这种关联都存在。
