Nasiry R W, McIntosh J H, Byth K, Piper D W
Gut. 1987 May;28(5):533-40. doi: 10.1136/gut.28.5.533.
The aim of this prospective study of 370 community based duodenal ulcer patients was to define the effect on duodenal ulcer course (from the aspect of symptom occurrence) of demographic and environmental factors, and of proven healing of index ulcer within four months. Follow up was three monthly, for up to three years. By survival analysis, it was found that marriage breakup adversely affected duodenal ulcer course, that age 50 years and under, female sex, and aspirin use tended to do so, and that smoking, alcohol ingestion, and paracetamol use did not. Proven healing of index ulcer within four months was associated with a small and non-significant reduction in symptom occurrence over time.
这项针对370名社区十二指肠溃疡患者的前瞻性研究旨在确定人口统计学和环境因素以及确诊的指数溃疡在四个月内愈合对十二指肠溃疡病程（从症状出现方面）的影响。随访每三个月进行一次，最长三年。通过生存分析发现，婚姻破裂对十二指肠溃疡病程有不利影响，50岁及以下、女性以及使用阿司匹林往往也有不利影响，而吸烟、饮酒和使用扑热息痛则没有。确诊的指数溃疡在四个月内愈合与症状随时间出现的小幅且不显著减少有关。
