Semi-supervised medical image segmentation via weak-to-strong perturbation consistency and edge-aware contrastive representation.

Despite that supervised learning has demonstrated impressive accuracy in medical image segmentation, its reliance on large labeled datasets poses a challenge due to the effort and expertise required for data acquisition. Semi-supervised learning has emerged as a potential solution. However, it tends to yield satisfactory segmentation performance in the central region of the foreground, but struggles in the edge region. In this paper, we propose an innovative framework that effectively leverages unlabeled data to improve segmentation performance, especially in edge regions. Our proposed framework includes two novel designs. Firstly, we introduce a weak-to-strong perturbation strategy with corresponding feature-perturbed consistency loss to efficiently utilize unlabeled data and guide our framework in learning reliable regions. Secondly, we propose an edge-aware contrastive loss that utilizes uncertainty to select positive pairs, thereby learning discriminative pixel-level features in the edge regions using unlabeled data. In this way, the model minimizes the discrepancy of multiple predictions and improves representation ability, ultimately aiming at impressive performance on both primary and edge regions. We conducted a comparative analysis of the segmentation results on the publicly available BraTS2020 dataset, LA dataset, and the 2017 ACDC dataset. Through extensive quantification and visualization experiments under three standard semi-supervised settings, we demonstrate the effectiveness of our approach and set a new state-of-the-art for semi-supervised medical image segmentation. Our code is released publicly at https://github.com/youngyzzZ/SSL-w2sPC.