Ghahramani Yasamin, Tabibi Seyedeh Sara, Khan Mohammad Mizanur Rahman, Asadi Alireza, Mohammadi Elaheh, Khaksar Ehsan, Khaksar Erfan, Kalashgrani Masoomeh Yari, Rahman Mohammed M, Chiang Wei-Hung, Mousavi Seyyed Mojtaba
Oral and Dental Disease Research Center, Department of Endodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Orthodintic Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Talanta. 2025 May 1;286:127494. doi: 10.1016/j.talanta.2024.127494. Epub 2024 Dec 31.
Bioactive materials and biosensing technologies are emerging as pivotal tools in the early detection and management of oral cancer, a disease characterized by high morbidity and mortality rates. Recent advancements in nanotechnology have facilitated the development of innovative biosensors that utilize bioactive materials for non-invasive diagnostics, particularly through salivary analysis. These biosensors, including electrochemical, optical, and molecular types, target specific biomarkers such as DNA, RNA, and proteins associated with oral cancer. For instance, metal oxide nanoparticles and gold nanoparticles have shown promise in enhancing the sensitivity and specificity of these diagnostic tools. The integration of these nanomaterials allows for real-time monitoring of biomarker levels in saliva, providing a rapid and accurate means of detecting oral cancer at its nascent stages. Furthermore, the utilization of biosensors can circumvent the limitations of traditional biopsy methods, which are often invasive and time-consuming. By focusing on salivary diagnostics, researchers aim to develop point-of-care testing devices that can be used in various settings, thus improving accessibility to early screening for at-risk populations. This innovative approach not only enhances diagnostic accuracy but also holds potential for personalized treatment strategies by enabling continuous monitoring of disease progression and response to therapy. As research continues to evolve, the combination of bioactive materials with advanced biosensing technologies promises to revolutionize oral cancer diagnostics, ultimately leading to improved patient outcomes through earlier intervention and tailored therapeutic approaches.
生物活性材料和生物传感技术正成为口腔癌早期检测和管理的关键工具，口腔癌是一种发病率和死亡率都很高的疾病。纳米技术的最新进展推动了创新型生物传感器的开发，这些传感器利用生物活性材料进行非侵入性诊断，特别是通过唾液分析。这些生物传感器，包括电化学、光学和分子类型，针对与口腔癌相关的特定生物标志物，如DNA、RNA和蛋白质。例如，金属氧化物纳米颗粒和金纳米颗粒在提高这些诊断工具的灵敏度和特异性方面显示出前景。这些纳米材料的整合使得能够实时监测唾液中的生物标志物水平，为在口腔癌早期阶段进行快速准确的检测提供了一种手段。此外，生物传感器的使用可以规避传统活检方法的局限性，传统活检方法往往具有侵入性且耗时。通过专注于唾液诊断，研究人员旨在开发可在各种环境中使用的即时检测设备，从而提高高危人群早期筛查的可及性。这种创新方法不仅提高了诊断准确性，还通过持续监测疾病进展和对治疗的反应，为个性化治疗策略带来了潜力。随着研究的不断发展，生物活性材料与先进生物传感技术的结合有望彻底改变口腔癌诊断，最终通过早期干预和量身定制的治疗方法改善患者预后。
